Exhaled breath analysis using electronic nose and gas chromatography–mass spectrometry for non-invasive diagnosis of chronic kidney disease, diabetes mellitus and healthy subjects

• Published in: Sensors and actuators. B, Chemical Vol. 257; pp. 178 - 188
• Main Authors: Saidi, Tarik, Zaim, Omar, Moufid, Mohammed, El Bari, Nezha, Ionescu, Radu, Bouchikhi, Benachir
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01.03.2018; Elsevier Science Ltd
• Subjects: Breath analysis; Breath tests; Chemical sensors; Chemometrics; Chromatography; Chronic kidney diseases; Cluster analysis; Creatinine; Diabetes; Diabetes mellitus; Diagnosis; Electronic nose; Electronic noses; Gas chromatography; Gas chromatography quadrupole time-of-flight mass spectrometry; Gas sensors; Kidney diseases; Mass spectrometry; Medical diagnosis; Organic chemistry; Pattern recognition; Principal components analysis; Quadrupoles; Regression analysis; Regression models; Spectrophotometry; Spectroscopy; Support vector machines; Urine; VOCs; Volatile organic compounds; Gas chromatography quadrupole time-of-flight mass spectrometry; Diabetes mellitus; Chemometrics; Breath analysis; Electronic nose; Chronic kidney diseases

[Display omitted] •E-nose and GC/Q-TOF-MS were employed to investigate breath of CKD, DM and HS.•GC/Q-TOF-MS detected special breath VOCs with high concentrations for each case.•E-nose could characterize breath patterns of CKD, DM as well as HSHC and HSLC.•Eight new cases, i.e. 2 CKD, 2 DM, 2 HSHC a...