Niosomes as carriers for tretinoin. I. Preparation and properties

Tretinoin-loaded niosomes were prepared from polyoxyethylene ( 4) lauryl ether, sorbitan esters and a commercial mixture of octyl/decyl polyglucosides, in the presence of cholesterol and dicetyl phosphate. Liposomes made of hydrogenated and non-hydrogenated phosphatidylcholine were also prepared as...

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Published inInternational journal of pharmaceutics Vol. 234; no. 1; pp. 237 - 248
Main Authors Manconi, Maria, Sinico, Chiara, Valenti, Donatella, Loy, Giuseppe, Fadda, Anna M
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 02.03.2002
Elsevier
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Abstract Tretinoin-loaded niosomes were prepared from polyoxyethylene ( 4) lauryl ether, sorbitan esters and a commercial mixture of octyl/decyl polyglucosides, in the presence of cholesterol and dicetyl phosphate. Liposomes made of hydrogenated and non-hydrogenated phosphatidylcholine were also prepared as a comparison reference. A study was made of the influence of vesicle composition and preparation method on the vesicle structure (MLV, LUV, SUV), size distribution, entrapment efficiency and in vitro release of incorporated tretinoin. Results showed that in the presence of cholesterol all the amphiphiles used were able to form stable vesicle dispersions with or without tretinoin. Vesicle sizes were dependent on the preparation method, bilayer composition and drug load. Multilamellar (MLV) vesicles were larger than extruded (LUV) and sonicated (SUV) vesicles while drug-loaded vesicles were generally smaller than empty ones. Entrapment efficiencies of tretinoin were always very high especially for multilamellar (91–99%) and extruded (88–98%) vesicles. The in vitro release of tretinoin from the prepared vesicular formulations was studied using the vertical Franz diffusion cells. The rate of drug release through a Silastic membrane from a liposomal and niosomal tretinoin dispersion was generally faster than from a tretinoin solution. Release data showed that tretinoin delivery is mainly affected by the vesicular structure and that tretinoin delivery increased from MLVs to LUVs to SUVs.
AbstractList Tretinoin-loaded niosomes were prepared from polyoxyethylene ( 4) lauryl ether, sorbitan esters and a commercial mixture of octyl/decyl polyglucosides, in the presence of cholesterol and dicetyl phosphate. Liposomes made of hydrogenated and non-hydrogenated phosphatidylcholine were also prepared as a comparison reference. A study was made of the influence of vesicle composition and preparation method on the vesicle structure (MLV, LUV, SUV), size distribution, entrapment efficiency and in vitro release of incorporated tretinoin. Results showed that in the presence of cholesterol all the amphiphiles used were able to form stable vesicle dispersions with or without tretinoin. Vesicle sizes were dependent on the preparation method, bilayer composition and drug load. Multilamellar (MLV) vesicles were larger than extruded (LUV) and sonicated (SUV) vesicles while drug-loaded vesicles were generally smaller than empty ones. Entrapment efficiencies of tretinoin were always very high especially for multilamellar (91–99%) and extruded (88–98%) vesicles. The in vitro release of tretinoin from the prepared vesicular formulations was studied using the vertical Franz diffusion cells. The rate of drug release through a Silastic membrane from a liposomal and niosomal tretinoin dispersion was generally faster than from a tretinoin solution. Release data showed that tretinoin delivery is mainly affected by the vesicular structure and that tretinoin delivery increased from MLVs to LUVs to SUVs.
Tretinoin-loaded niosomes were prepared from polyoxyethylene (4) lauryl ether, sorbitan esters and a commercial mixture of octyl/decyl polyglucosides, in the presence of cholesterol and dicetyl phosphate. Liposomes made of hydrogenated and non-hydrogenated phosphatidylcholine were also prepared as a comparison reference. A study was made of the influence of vesicle composition and preparation method on the vesicle structure (MLV, LUV, SUV), size distribution, entrapment efficiency and in vitro release of incorporated tretinoin. Results showed that in the presence of cholesterol all the amphiphiles used were able to form stable vesicle dispersions with or without tretinoin. Vesicle sizes were dependent on the preparation method, bilayer composition and drug load. Multilamellar (MLV) vesicles were larger than extruded (LUV) and sonicated (SUV) vesicles while drug-loaded vesicles were generally smaller than empty ones. Entrapment efficiencies of tretinoin were always very high especially for multilamellar (91-99%) and extruded (88-98%) vesicles. The in vitro release of tretinoin from the prepared vesicular formulations was studied using the vertical Franz diffusion cells. The rate of drug release through a Silastic membrane from a liposomal and niosomal tretinoin dispersion was generally faster than from a tretinoin solution. Release data showed that tretinoin delivery is mainly affected by the vesicular structure and that tretinoin delivery increased from MLVs to LUVs to SUVs.
Author Sinico, Chiara
Fadda, Anna M
Valenti, Donatella
Manconi, Maria
Loy, Giuseppe
Author_xml – sequence: 1
  givenname: Maria
  surname: Manconi
  fullname: Manconi, Maria
– sequence: 2
  givenname: Chiara
  surname: Sinico
  fullname: Sinico, Chiara
– sequence: 3
  givenname: Donatella
  surname: Valenti
  fullname: Valenti, Donatella
– sequence: 4
  givenname: Giuseppe
  surname: Loy
  fullname: Loy, Giuseppe
– sequence: 5
  givenname: Anna M
  surname: Fadda
  fullname: Fadda, Anna M
  email: mfadda@unica.it
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https://www.ncbi.nlm.nih.gov/pubmed/11839454$$D View this record in MEDLINE/PubMed
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Keywords In vitro release
Non-ionic surfactant vesicles
Liposomes
Niosomes
Tretinoin
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– volume: 178
  start-page: 263
  year: 1996
  ident: 10.1016/S0378-5173(01)00971-1_BIB35
  article-title: Preparation and characterization of nonionic surfactant vesicles
  publication-title: J. Coll. Interf. Sci.
  doi: 10.1006/jcis.1996.0114
  contributor:
    fullname: Van Hal
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Snippet Tretinoin-loaded niosomes were prepared from polyoxyethylene ( 4) lauryl ether, sorbitan esters and a commercial mixture of octyl/decyl polyglucosides, in the...
Tretinoin-loaded niosomes were prepared from polyoxyethylene (4) lauryl ether, sorbitan esters and a commercial mixture of octyl/decyl polyglucosides, in the...
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StartPage 237
SubjectTerms Biological and medical sciences
Cholesterol
Diffusion
Drug Carriers
General pharmacology
In vitro release
Keratolytic Agents - administration & dosage
Lasers
Light
Liposomes
Medical sciences
Membranes, Artificial
Microscopy, Electron
Microspheres
Niosomes
Non-ionic surfactant vesicles
Organophosphates
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Scattering, Radiation
Skin, nail, hair, dermoskeleton
Tretinoin
Tretinoin - administration & dosage
Title Niosomes as carriers for tretinoin. I. Preparation and properties
URI https://dx.doi.org/10.1016/S0378-5173(01)00971-1
https://www.ncbi.nlm.nih.gov/pubmed/11839454
https://search.proquest.com/docview/71432154
Volume 234
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