Susceptibility of infarcted canine hearts to digitalis-toxic ventricular tachycardia

• Published in: Journal of the American College of Cardiology Vol. 2; no. 1; pp. 45 - 51
• Main Authors: Iesaka, Yoshito, Aonuma, Kazutaka, Gosselin, Arthur J., Pinakatt, Teresa, Stanford, William, Benson, Jerome, Sampsell, Ronald, Rozanski, John J., Lister, John W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.1983
• Subjects: Animals; digitalis; Digitalis Glycosides - administration & dosage; Disease Models, Animal; Disease Susceptibility; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Heart Septum - physiopathology; Heart Ventricles - physiopathology; Myocardial Infarction - complications; Ouabain - administration & dosage; Tachycardia - chemically induced; Tachycardia - complications; Tachycardia - physiopathology

The susceptibility to the toxic arrhythmogenic effects of digitalis was studied in 10 normal dogs (group 1) and in 15 dogs with healed myocardial infarction (group 2) 26 ± 5 days after coronary artery ligation. The dose of ouabain required to cause stable digitalis-toxic ventricular tachycardia was...