CellTalkDB: a manually curated database of ligand–receptor interactions in humans and mice

• Published in: Briefings in bioinformatics Vol. 22; no. 4
• Main Authors: Shao, Xin, Liao, Jie, Li, Chengyu, Lu, Xiaoyan, Cheng, Junyun, Fan, Xiaohui
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2021; Oxford Publishing Limited (England)
• Subjects: Biological activity; Cell interactions; Communications; Data mining; Gene sequencing; Heterogeneity; Ligands; Protein interaction; Proteins; Receptors; cell–cell-communication; ligand–receptor interaction; mouse; single-cell transcriptomics; scRNA-seq; human

Abstract Cell–cell communications in multicellular organisms generally involve secreted ligand–receptor (LR) interactions, which is vital for various biological phenomena. Recent advancements in single-cell RNA sequencing (scRNA-seq) have effectively resolved cellular phenotypic heterogeneity and th...