Reflections on the tissue kallikrein and kallikrein-related peptidase family – from mice to men – what have we learnt in the last two decades?

• Published in: Biological chemistry Vol. 389; no. 12; pp. 1447 - 1454
• Main Author: Clements, Judith A
• Format: Journal Article
• Language: English
• Published: Germany Walter de Gruyter 01.12.2008
• Subjects: Animals; expression; function; gene clusters; Gene Expression Regulation - genetics; glandular kallikrein (GK); hormonal regulation; Humans; kallikrein-related (KLK); Mice; Peptide Hydrolases - genetics; Peptide Hydrolases - metabolism; Tissue Kallikreins - genetics; Tissue Kallikreins - metabolism

The genes encoding the kininogenase, glandular tissue kallikrein, in rodents and man were first described in the mid-1980s. Remarkably, they appeared to be part of a much larger highly conserved family of genes (GK) in rodents, but only had two paralogs in man. This discrepancy was not rectified unt...