Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects

• Published in: European journal of pharmacology Vol. 450; no. 3; pp. 277 - 289
• Main Authors: Čulić, Ognjen, Eraković, Vesna, Čepelak, Ivana, Barišić, Karmela, Brajša, Karmen, Ferenčić, Željko, Galović, Ružica, Glojnarić, Ines, Manojlović, Zoran, Munić, Vesna, Novak-Mirčetić, Renata, Pavičić-Beljak, Verica, Sučić, Mirna, Veljača, Marija, Žanić-Grubišić, Tihana, Parnham, Michael J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 30.08.2002; Elsevier
• Subjects: Acute-Phase Proteins - analysis; Administration, Oral; Adult; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - blood; Anti-Inflammatory Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antioxidants - metabolism; Apoptosis; Azithromycin; Azithromycin - administration & dosage; Azithromycin - blood; Azithromycin - pharmacology; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Cell Adhesion Molecules - blood; Chemokines - blood; Cytokine; Cytokines - blood; Degranulation; Enzyme-Linked Immunosorbent Assay; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Glutathione Reductase - metabolism; Human volunteer; Humans; Male; Medical sciences; Neutrophil; Neutrophils - cytology; Neutrophils - drug effects; Neutrophils - metabolism; Nitrates - blood; Nitrites - blood; Oxidative burst; Oxidative Stress - drug effects; Pharmacology. Drug treatments; Superoxide Dismutase - metabolism; Degranulation; Neutrophil; Human volunteer; Azithromycin; Oxidative burst; Cytokine; Human; Oxidative stress; Healthy subject; Antiinflammatory agent; Oral administration; Inflammation; Oxidant; Macrolide; Antibiotic; Cell death; Inflammatory cell; Antibacterial agent; Mechanism of action; Apoptosis

Effects on human neutrophils and circulating inflammatory mediators were studied in 12 volunteers who received azithromycin (500 mg/day, p.o.) for 3 days. Blood was taken 1 h before treatment, 2.5, 24 h and 28 days after the last dose. An initial neutrophil degranulating effect of azithromycin was r...