Lack of association between IRF5 gene polymorphisms and biopsy-proven giant cell arteritis

• Published in: Journal of rheumatology Vol. 37; no. 1; p. 136
• Main Authors: Torres, Orlando, Palomino-Morales, Rogelio, Vazquez-Rodriguez, Tomas R, Castañeda, Santos, Morado, Inmaculada C, Miranda-Filloy, Jose A, Valero, Fernando, Callejas-Rubio, Jose L, Fernandez-Gutierrez, Benjamin, Martin, Javier, Gonzalez-Gay, Miguel A
• Format: Journal Article
• Language: English
• Published: Canada 01.01.2010
• Subjects: Aged; Aged, 80 and over; Biopsy; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Giant Cell Arteritis - diagnosis; Giant Cell Arteritis - genetics; Giant Cell Arteritis - pathology; Giant Cell Arteritis - surgery; Humans; Interferon Regulatory Factors - genetics; Middle Aged; Polymorphism, Genetic

Interferon (IFN) regulatory factors (IRF) are transcriptional mediators of IFN-induced signaling pathways and are involved in immune response. We have analyzed for the first time the association of 2 IRF5 gene variants in the susceptibility to giant cell arteritis (GCA). Two hundred twenty patients...