Distribution of parkin in the adult rat brain
A mutation in the parkin gene has been identified as the cause for an autosomal recessively inherited form of Parkinson's disease (PD). The authors have recently isolated the mRNA coding for the rat homolog of parkin and showed its widespread expression in the central nervous system (CNS) by in...
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Published in | Progress in neuro-psychopharmacology & biological psychiatry Vol. 26; no. 3; pp. 519 - 527 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.04.2002
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Abstract | A mutation in the parkin gene has been identified as the cause for an autosomal recessively inherited form of Parkinson's disease (PD). The authors have recently isolated the mRNA coding for the rat homolog of parkin and showed its widespread expression in the central nervous system (CNS) by in situ hybridization. In the present study, we investigated the distribution of parkin in the rat CNS with a polyclonal antibody that reacts with a ∼52-kDa protein, mainly localized in the cytoplasm and corresponding to the predicted molecular mass of parkin. Immunohistochemistry on adult rat brain sections showed a widespread distribution of parkin. This included labeling of cell bodies, nuclei as well as processes in the hippocampus, cerebral cortex, cerebellum, and several nuclei in the brainstem. The regional expression of parkin-immunoreactivity (IR) correlated well with the parkin-mRNA levels assessed by real-time quantitative reverse transcription–polymerase chain reaction (RT-PCR). This study provides the detailed analysis of the regional and cellular distribution of parkin in the rat brain and may be useful in elucidating its pathophysiological role. |
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AbstractList | A mutation in the parkin gene has been identified as the cause for an autosomal recessively inherited form of Parkinson's disease (PD). The authors have recently isolated the mRNA coding for the rat homolog of parkin and showed its widespread expression in the central nervous system (CNS) by in situ hybridization. In the present study, we investigated the distribution of parkin in the rat CNS with a polyclonal antibody that reacts with a approximately 52-kDa protein, mainly localized in the cytoplasm and corresponding to the predicted molecular mass of parkin. Immunohistochemistry on adult rat brain sections showed a widespread distribution of parkin. This included labeling of cell bodies, nuclei as well as processes in the hippocampus, cerebral cortex, cerebellum, and several nuclei in the brainstem. The regional expression of parkin-immunoreactivity (IR) correlated well with the parkin-mRNA levels assessed by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR). This study provides the detailed analysis of the regional and cellular distribution of parkin in the rat brain and may be useful in elucidating its pathophysiological role. A mutation in the parkin gene has been identified as the cause for an autosomal recessively inherited form of Parkinson's disease (PD). The authors have recently isolated the mRNA coding for the rat homolog of parkin and showed its widespread expression in the central nervous system (CNS) by in situ hybridization. In the present study, we investigated the distribution of parkin in the rat CNS with a polyclonal antibody that reacts with a ∼52-kDa protein, mainly localized in the cytoplasm and corresponding to the predicted molecular mass of parkin. Immunohistochemistry on adult rat brain sections showed a widespread distribution of parkin. This included labeling of cell bodies, nuclei as well as processes in the hippocampus, cerebral cortex, cerebellum, and several nuclei in the brainstem. The regional expression of parkin-immunoreactivity (IR) correlated well with the parkin-mRNA levels assessed by real-time quantitative reverse transcription–polymerase chain reaction (RT-PCR). This study provides the detailed analysis of the regional and cellular distribution of parkin in the rat brain and may be useful in elucidating its pathophysiological role. |
Author | D'Agata, Velia Scapagnini, Giovanni Zhao, Weiqin Pascale, Alessia Zohar, Ofer Cavallaro, Sebastiano |
Author_xml | – sequence: 1 givenname: Velia surname: D'Agata fullname: D'Agata, Velia email: vdagata@brni-jhu.org organization: Institute of Bioimaging and Pathophysiology of the Central Nervous System, Italian National Research Council, Catania, Italy – sequence: 2 givenname: Weiqin surname: Zhao fullname: Zhao, Weiqin organization: Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, MD, USA – sequence: 3 givenname: Alessia surname: Pascale fullname: Pascale, Alessia organization: Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, MD, USA – sequence: 4 givenname: Ofer surname: Zohar fullname: Zohar, Ofer organization: Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, MD, USA – sequence: 5 givenname: Giovanni surname: Scapagnini fullname: Scapagnini, Giovanni organization: Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, MD, USA – sequence: 6 givenname: Sebastiano surname: Cavallaro fullname: Cavallaro, Sebastiano organization: Institute of Bioimaging and Pathophysiology of the Central Nervous System, Italian National Research Council, Catania, Italy |
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Keywords | Immunohistochemistry Parkinson's disease Central nervous system ARJP CNS IR l-dopa SNc PD SNr Autosomal recessive juvenile parkinsonism Distribution IBR Nervous system diseases Rat Pathogenesis Gene product Rodentia Parkinson disease Gene expression Protein Cerebral disorder Vertebrata Mammalia Animal Central nervous system disease Degenerative disease Extrapyramidal syndrome Brain (vertebrata) |
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Snippet | A mutation in the parkin gene has been identified as the cause for an autosomal recessively inherited form of Parkinson's disease (PD). The authors have... |
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SubjectTerms | Animals Autosomal recessive juvenile parkinsonism Biological and medical sciences Brain - cytology Brain - metabolism Brain Chemistry - physiology Central nervous system Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Distribution Immunohistochemistry Ligases - analysis Ligases - biosynthesis Male Medical sciences Neurology Parkinson's disease Rats Rats, Wistar RNA, Messenger - analysis RNA, Messenger - biosynthesis Ubiquitin-Protein Ligases |
Title | Distribution of parkin in the adult rat brain |
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