Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication - Tsukamoto, Yuta; Hiono, Takahiro; Yamada, Shintaro; Matsuno, Keita; Faist, Aileen; Claff, Tobias; Hou, Jianyu; Namasivayam, Vigneshwaran; vom Hemdt, Anja; Sugimoto, Satoko; Ng, Jin Ying; Christensen, Maria H.; et al. (Science (American Association for the Advancement of Science), 2023)
Keywords: A549 Cells; Alphainfluenzavirus - drug effects; Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Betainfluenzavirus - drug effects; Biological Products - chemistry; Biological Products - pharmacology; Computer Simulation; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Humans; Influenza; Maturation; Methyltransferases - antagonists & inhibitors; Mice; Replication; Ribonucleic acid; RNA; RNA Caps - metabolism; RNA viruses; RNA, Messenger - metabolism; RNA, Viral - biosynthesis; Streptomyces - chemistry; Toxicity; Tubercidin - analogs & derivatives; Tubercidin - pharmacology; Virus Replication - drug effects; Viruses