Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration

• Published in: Stem cells and development Vol. 21; no. 2; p. 228
• Main Authors: Maijenburg, Marijke W, Gilissen, Christian, Melief, Sara M, Kleijer, Marion, Weijer, Kees, Ten Brinke, Anja, Roelofs, Helene, Van Tiel, Claudia M, Veltman, Joris A, de Vries, Carlie J M, van der Schoot, C Ellen, Voermans, Carlijn
• Format: Journal Article
• Language: English
• Published: United States 20.01.2012
• Subjects: Bone Marrow - physiology; Cell Cycle - drug effects; Cell Cycle - genetics; Cell Movement - drug effects; Cell Movement - genetics; Cell Proliferation - drug effects; Cells, Cultured; Chemokine CXCL12 - pharmacology; Fetus; Gene Expression Profiling; Gene Expression Regulation - drug effects; Hepatocyte Growth Factor - genetics; Hepatocyte Growth Factor - metabolism; Humans; Interleukin-6 - biosynthesis; Interleukin-8 - biosynthesis; Lentivirus; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - metabolism; Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics; Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism; Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics; Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism; Proto-Oncogene Proteins c-sis - pharmacology; Signal Transduction - drug effects; T-Lymphocytes - cytology; T-Lymphocytes - metabolism; Transfection

Detailed understanding of mesenchymal stromal cells (MSC) migration is imperative for future cellular therapies. To identify genes involved in the process of MSC migration, we generated gene expression profiles of migrating and nonmigrating fetal bone marrow MSC (FBMSC). Only 12 genes showed differe...