Toxic effects of microbial phenolic acids on the functions of mitochondria

• Published in: Toxicology letters Vol. 180; no. 3; pp. 182 - 188
• Main Authors: Fedotcheva, N.I., Kazakov, R.E., Kondrashova, M.N., Beloborodova, N.V.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 28.08.2008
• Subjects: Adenosine Diphosphate - metabolism; Animals; Bacteria - chemistry; Cyclosporine - pharmacology; Electron Transport - drug effects; Hydroxybenzoates - chemistry; Hydroxybenzoates - toxicity; Male; Membrane Potentials - drug effects; Mitochondria - drug effects; Mitochondrial dysfunction; Oxygen Consumption - drug effects; Phenolic acids; Rats; Reactive Oxygen Species; ROS; Sepsis; Structure-Activity Relationship; Vitamin K 3 - pharmacology; Sepsis; Mitochondrial dysfunction; Phenolic acids; ROS

Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionаte, р-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially the products of the degradation of aromatic amino acids and polyphenols by the intestinal microflora. In sepsis, the concentrations of some of...