Toxic effects of microbial phenolic acids on the functions of mitochondria
Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionаte, р-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially the products of the degradation of aromatic amino acids and polyphenols by the intestinal microflora. In sepsis, the concentrations of some of...
Saved in:
Published in | Toxicology letters Vol. 180; no. 3; pp. 182 - 188 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ireland Ltd
28.08.2008
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionаte,
р-hydroxyphenyllactate, and
p-hydroxyphenylacetate are essentially the products of the degradation of aromatic amino acids and polyphenols by the intestinal microflora. In sepsis, the concentrations of some of these acids in the blood increase tens of times. Assuming that these compounds can cause the mitochondrial dysfunction in sepsis, we examined their effects on respiration, the induction of pore opening, and the production of reactive oxygen species (ROS) in mitochondria. It was found that phenylpropionаte and phenylacetate produce a more toxic effect on mitochondria than the other phenolic acids. At concentrations 0.01–0.1
mM they decreased the rate of oxidation of NAD-dependent substrates and activated the Ca
2+- and menadione-induced opening of the cyclosporin A-sensitive pore and the production of ROS. The disturbances caused by these PhAs are similar to those observed in mitochondria in sepsis, and hence the rise in their level may be one of the causes of mitochondrial dysfunctions. Phenyllactate,
р-hydroxyphenyllactate, and
p-hydroxyphenylacetate inhibited the production of ROS and pore opening, acting as antioxidants. Thus, the ability of PhAs to affect the mitochondrial functions, as well as an increase in their concentrations in sepsis (the total concentration of these PhAs in the blood is close to 0.1
mM), suggests that PhAs can be directly involved in the development of mitochondrial failure. |
---|---|
AbstractList | Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionate, p-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially the products of the degradation of aromatic amino acids and polyphenols by the intestinal microflora. In sepsis, the concentrations of some of these acids in the blood increase tens of times. Assuming that these compounds can cause the mitochondrial dysfunction in sepsis, we examined their effects on respiration, the induction of pore opening, and the production of reactive oxygen species (ROS) in mitochondria. It was found that phenylpropionate and phenylacetate produce a more toxic effect on mitochondria than the other phenolic acids. At concentrations 0.01-0.1 mM they decreased the rate of oxidation of NAD-dependent substrates and activated the Ca2+- and menadione-induced opening of the cyclosporin A-sensitive pore and the production of ROS. The disturbances caused by these PhAs are similar to those observed in mitochondria in sepsis, and hence the rise in their level may be one of the causes of mitochondrial dysfunctions. Phenyllactate, p-hydroxyphenyllactate, and p-hydroxyphenylacetate inhibited the production of ROS and pore opening, acting as antioxidants. Thus, the ability of PhAs to affect the mitochondrial functions, as well as an increase in their concentrations in sepsis (the total concentration of these PhAs in the blood is close to 0.1 mM), suggests that PhAs can be directly involved in the development of mitochondrial failure. Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropion?te, ?-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially the products of the degradation of aromatic amino acids and polyphenols by the intestinal microflora. In sepsis, the concentrations of some of these acids in the blood increase tens of times. Assuming that these compounds can cause the mitochondrial dysfunction in sepsis, we examined their effects on respiration, the induction of pore opening, and the production of reactive oxygen species (ROS) in mitochondria. It was found that phenylpropion?te and phenylacetate produce a more toxic effect on mitochondria than the other phenolic acids. At concentrations 0.01-0.1mM they decreased the rate of oxidation of NAD-dependent substrates and activated the Ca super(2) super(+)- and menadione-induced opening of the cyclosporin A-sensitive pore and the production of ROS. The disturbances caused by these PhAs are similar to those observed in mitochondria in sepsis, and hence the rise in their level may be one of the causes of mitochondrial dysfunctions. Phenyllactate, ?-hydroxyphenyllactate, and p-hydroxyphenylacetate inhibited the production of ROS and pore opening, acting as antioxidants. Thus, the ability of PhAs to affect the mitochondrial functions, as well as an increase in their concentrations in sepsis (the total concentration of these PhAs in the blood is close to 0.1mM), suggests that PhAs can be directly involved in the development of mitochondrial failure. Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionаte, р-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially the products of the degradation of aromatic amino acids and polyphenols by the intestinal microflora. In sepsis, the concentrations of some of these acids in the blood increase tens of times. Assuming that these compounds can cause the mitochondrial dysfunction in sepsis, we examined their effects on respiration, the induction of pore opening, and the production of reactive oxygen species (ROS) in mitochondria. It was found that phenylpropionаte and phenylacetate produce a more toxic effect on mitochondria than the other phenolic acids. At concentrations 0.01–0.1 mM they decreased the rate of oxidation of NAD-dependent substrates and activated the Ca 2+- and menadione-induced opening of the cyclosporin A-sensitive pore and the production of ROS. The disturbances caused by these PhAs are similar to those observed in mitochondria in sepsis, and hence the rise in their level may be one of the causes of mitochondrial dysfunctions. Phenyllactate, р-hydroxyphenyllactate, and p-hydroxyphenylacetate inhibited the production of ROS and pore opening, acting as antioxidants. Thus, the ability of PhAs to affect the mitochondrial functions, as well as an increase in their concentrations in sepsis (the total concentration of these PhAs in the blood is close to 0.1 mM), suggests that PhAs can be directly involved in the development of mitochondrial failure. |
Author | Kazakov, R.E. Beloborodova, N.V. Fedotcheva, N.I. Kondrashova, M.N. |
Author_xml | – sequence: 1 givenname: N.I. surname: Fedotcheva fullname: Fedotcheva, N.I. email: nfedotcheva@mail.ru organization: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290 Russia – sequence: 2 givenname: R.E. surname: Kazakov fullname: Kazakov, R.E. organization: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290 Russia – sequence: 3 givenname: M.N. surname: Kondrashova fullname: Kondrashova, M.N. organization: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290 Russia – sequence: 4 givenname: N.V. surname: Beloborodova fullname: Beloborodova, N.V. organization: Bakulev Scientific Center for Cardiovascular Surgery, Moscow, Russia |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18634861$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kLtOwzAUhi1UREvhDRDKxJZgx47jLkio4qpKLGW2HPtEdZXYJU5QeXtcJRIb0xnO95_Ld4lmzjtA6IbgjGDC7_dZ748N9FmOscgwzwQnZ2hBRLlKKeGrGVpgWoqU5SWbo8sQ9hhjznhxgeZEcMoiv0DvW3-0OoG6Bt2HxNdJa3XnK6ua5LAD55vYVdqa2HNJv4OkHpzurXcT3Hu98850Vl2h81o1Aa6nukSfz0_b9Wu6-Xh5Wz9uUk1XpE-rWpE8F1DQotLx9pLmJQZTgBGMllVhCCgFRcVVGY8ygosCc8LyylS0LhjQJbob5x46_zVA6GVrg4amUQ78EGSOVzznmEWQjWB8KIQOannobKu6H0mwPDmUezk6lCeHEnMZncTY7TR_qFowf6FJWgQeRgDil98WOhm0BafB2C5alMbb_zf8Ari_h3Q |
CitedBy_id | crossref_primary_10_1016_j_jpba_2019_112883 crossref_primary_10_1016_j_lwt_2022_113122 crossref_primary_10_1021_tx200126r crossref_primary_10_1039_C5RA09464J crossref_primary_10_1371_journal_pone_0160840 crossref_primary_10_1134_S0006297909120086 crossref_primary_10_1134_S1990747810010083 crossref_primary_10_1186_1423_0127_19_89 crossref_primary_10_1016_j_ecoenv_2022_113704 crossref_primary_10_15360_1813_9779_2018_5_96_119 crossref_primary_10_1016_j_jcrc_2017_09_014 crossref_primary_10_1093_ajcn_nqy249 crossref_primary_10_1111_j_1462_2920_2011_02669_x crossref_primary_10_1371_journal_pone_0217180 crossref_primary_10_3390_nu15030649 crossref_primary_10_3390_toxics10030140 crossref_primary_10_1016_j_ibiod_2013_05_011 crossref_primary_10_3389_fphar_2018_00653 crossref_primary_10_3109_03602532_2014_908903 crossref_primary_10_1016_j_cbi_2013_09_009 crossref_primary_10_1134_S0006297915030128 crossref_primary_10_3945_jn_115_229179 crossref_primary_10_1016_j_bbadis_2023_166876 crossref_primary_10_1016_j_jchromb_2017_02_018 crossref_primary_10_1186_cc11713 crossref_primary_10_1186_s13054_020_03031_0 crossref_primary_10_3390_metabo9100196 crossref_primary_10_3390_biomedicines9050558 crossref_primary_10_1134_S0006350912050065 crossref_primary_10_25557_0031_2991_2018_01_97_108 crossref_primary_10_3389_fmolb_2018_00029 crossref_primary_10_1002_rcm_8971 crossref_primary_10_1097_CCM_0000000000005640 crossref_primary_10_1155_2019_4128682 crossref_primary_10_1134_S0006350915060068 crossref_primary_10_1016_j_bcp_2009_05_028 crossref_primary_10_1097_QAD_0000000000003363 crossref_primary_10_3390_metabo11020122 |
Cites_doi | 10.1080/089106000435545 10.1016/0014-5793(95)00411-2 10.1186/cc5984 10.1016/0891-5849(93)90013-K 10.1006/abio.2000.4542 10.1016/j.freeradbiomed.2004.06.044 10.1055/s-2006-957886 10.2131/jts.28.139 10.1016/0167-4838(84)90142-0 10.1097/01.CCM.0000278914.85340.FE 10.1128/JCM.16.4.747-750.1982 10.1080/15287399509532011 10.1016/j.mito.2004.07.023 10.1093/jn/130.11.2733 10.1128/JCM.11.6.743-745.1980 10.1093/ndt/gfm475 10.1021/jf0108056 10.1523/JNEUROSCI.20-01-00103.2000 10.1016/j.freeradbiomed.2005.09.014 10.1016/S0014-5793(98)00689-9 10.1074/jbc.M503090200 10.1016/S0021-9258(19)57189-7 10.1016/S1567-7249(01)00025-3 10.1007/s11908-003-0015-9 10.1021/ac00029a013 10.1042/bj20030670 10.1016/S0140-6736(02)09459-X 10.1016/j.freeradbiomed.2004.11.020 10.1097/01.ccm.0000281448.00095.4d 10.1093/jn/135.10.2343 10.1016/S0378-4347(96)00411-2 10.1055/s-1999-13956 10.1016/j.jacc.2006.02.069 10.1158/1078-0432.CCR-0747-3 10.1242/jcs.115.3.485 10.1152/ajpregu.00432.2003 10.1097/01.CCM.0000278604.93569.27 10.1096/fj.00-058rev 10.1007/BF01799945 10.1093/jn/130.8.2073S 10.1074/jbc.M607704200 10.1016/j.freeradbiomed.2006.02.012 10.1097/01.shk.0000235089.30550.2d 10.1080/10715769800300501 |
ContentType | Journal Article |
Copyright | 2008 Elsevier Ireland Ltd |
Copyright_xml | – notice: 2008 Elsevier Ireland Ltd |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7T7 7U7 8FD C1K FR3 P64 |
DOI | 10.1016/j.toxlet.2008.06.861 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Bacteriology Abstracts (Microbiology B) Industrial and Applied Microbiology Abstracts (Microbiology A) Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Technology Research Database Toxicology Abstracts Bacteriology Abstracts (Microbiology B) Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management |
DatabaseTitleList | MEDLINE Technology Research Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Public Health Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1879-3169 |
EndPage | 188 |
ExternalDocumentID | 10_1016_j_toxlet_2008_06_861 18634861 S0378427408010357 |
Genre | Journal Article |
GroupedDBID | --- --K --M .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29Q 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABEFU ABFNM ABFRF ABFYP ABJNI ABLST ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KCYFY KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSJ SSP SSZ T5K WH7 WUQ XPP ZGI ZXP ~G- ~KM AKRWK CGR CUY CVF ECM EIF NPM AAXKI AAYXX AFJKZ CITATION 7QL 7T7 7U7 8FD C1K FR3 P64 |
ID | FETCH-LOGICAL-c391t-bfa1228e535bc20073270ed5ed8437b5d1eaae5b6a7ffed868506142bdb3f54e3 |
IEDL.DBID | AIKHN |
ISSN | 0378-4274 |
IngestDate | Sat Aug 17 01:22:26 EDT 2024 Thu Sep 26 18:59:34 EDT 2024 Sat Sep 28 08:48:27 EDT 2024 Fri Feb 23 02:32:42 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | Sepsis Mitochondrial dysfunction Phenolic acids ROS |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c391t-bfa1228e535bc20073270ed5ed8437b5d1eaae5b6a7ffed868506142bdb3f54e3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 18634861 |
PQID | 20962604 |
PQPubID | 23462 |
PageCount | 7 |
ParticipantIDs | proquest_miscellaneous_20962604 crossref_primary_10_1016_j_toxlet_2008_06_861 pubmed_primary_18634861 elsevier_sciencedirect_doi_10_1016_j_toxlet_2008_06_861 |
PublicationCentury | 2000 |
PublicationDate | 2008-08-28 |
PublicationDateYYYYMMDD | 2008-08-28 |
PublicationDate_xml | – month: 08 year: 2008 text: 2008-08-28 day: 28 |
PublicationDecade | 2000 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Toxicology letters |
PublicationTitleAlternate | Toxicol Lett |
PublicationYear | 2008 |
Publisher | Elsevier Ireland Ltd |
Publisher_xml | – name: Elsevier Ireland Ltd |
References | Crouser (bib12) 2004; 4 Antoshechkin, Chentsova, Tatur, Naritsin, Railian (bib1) 1991; 14 Karlsson, Huss, Jenner, Halliwell, Bohlin, Rafter (bib22) 2005; 135 Fedotcheva, Sokolov, Kondrashova (bib15) 2006; 41 Wayne, Hatheway, Lambert, Mccroskey (bib46) 1980; 11 Genfa, Dasgupta (bib17) 1992; 64 Oberholzer, Oberholzer, Clare-Salzler, Moldawer (bib36) 2001; 15 Schmidt, Westhoff, Krauser, Zidek, van der Giet (bib42) 2008; 23 Chance, Williams (bib9) 1955; 217 Déprez, Brezillon, Rabot, Philippe, Mila, Lapierre, Scalbert (bib13) 2000; 130 Merfort, Heilmann, Weiss, Pietta, Gardana (bib34) 1996; 62 Jenner, Rafter, Halliwell (bib20) 2005; 38 Kuhlmann, Burkhardt, Horsch, Wagner, Köhler (bib25) 1998; 29 Galati, Lin, Sultan, O’Brien (bib16) 2006; 40 Gerasimenko, Gerasimenko, Palejwala, Tepikin, Petersen, Watson (bib18) 2002; 115 Panus, Radi, Chumley, Lillard, Freeman (bib37) 1993; 14 Scalbert, Williamson (bib41) 2000; 130 Mayrand, Bourgeau (bib33) 1982; 16 Li, Parikh, Shu, Jung, Chow, Perlaky, Leung, Su, Blaney, Lau (bib30) 2004; 10 Larche, Lancel, Hassoun, Favory, Decoster, Marchetti, Chopin, Neviere (bib27) 2006; 48 Brealey, Singer (bib5) 2003; 5 Chernyak, Dedov, Chernyak (bib10) 1995; 365 Levy (bib28) 2007; 28 Levy, Deutschman (bib29) 2007; 35 Brealey, Brand, Hargreaves, Heales, Land, Smolenski, Davies, Cooper, Singer (bib6) 2002; 360 Piel, Gruber, Weinheimer, Courtois, Robertson, Coopersmith, Deutschman, Levy (bib38) 2007; 35 Limasset, Ojasoo, le Doucen, Doré (bib31) 1999; 65 Henry, Solem, Wallace (bib19) 1995; 45 Kushnareva, Wiley, Ward, Andreyev, Murphy (bib26) 2005; 280 Shen (bib43) 1984; 785 Criddle, Gillies, Baumgartner-Wilson, Jaffar, Chinje, Passmore, Chvanov, Barrow, Gerasimenko, Tepikin, Sutton, Petersen (bib11) 2006; 281 Mani, Pannala, Orie, Ollosson, Harry, Rice-Evans, Moore (bib32) 2003; 374 Sarkissian, Scriver, Mamer (bib40) 2000; 280 Brealey, Karyampudi, Jacques, Novelli, Stidwill, Taylor, Smolenski, Singer (bib7) 2004; 286 Aura, O’Leary, Williamson, Ojala, Bailey, Puupponen-Pimiä, Nuutila, Oksman-Caldentey, Poutanen (bib2) 2002; 50 Brustovetsky, Dubinsky (bib8) 2000; 20 Beloborodova, Arkhipova, Beloborodov, Boiko, Melko, Olenin (bib4) 2006; 2 Kambayashi, Ogino (bib21) 2003; 28 Khodakova, Beloborodova (bib23) 2007; 11 Protti, Carré, Frost, Taylor, Stidwill, Rudiger, Singer (bib39) 2007; 35 Deutsch (bib14) 1997; 690 Kondrashova, Fedotcheva, Saakyan, Sirota, Lyamzaev, Kulikova, Temnov (bib24) 2001; 1/3 Tampo, Tsukamoto, Yonaha (bib44) 1998; 430 Toninello, Salvi, Schweizer, Richter (bib45) 2004; 37 Navas, García, González (bib35) 1955; 10 Beloborodova, Osipov (bib3) 2000; 12 Genfa (10.1016/j.toxlet.2008.06.861_bib17) 1992; 64 Brealey (10.1016/j.toxlet.2008.06.861_bib5) 2003; 5 Fedotcheva (10.1016/j.toxlet.2008.06.861_bib15) 2006; 41 Brealey (10.1016/j.toxlet.2008.06.861_bib6) 2002; 360 Li (10.1016/j.toxlet.2008.06.861_bib30) 2004; 10 Kondrashova (10.1016/j.toxlet.2008.06.861_bib24) 2001; 1/3 Antoshechkin (10.1016/j.toxlet.2008.06.861_bib1) 1991; 14 Beloborodova (10.1016/j.toxlet.2008.06.861_bib3) 2000; 12 Levy (10.1016/j.toxlet.2008.06.861_bib28) 2007; 28 Protti (10.1016/j.toxlet.2008.06.861_bib39) 2007; 35 Brealey (10.1016/j.toxlet.2008.06.861_bib7) 2004; 286 Panus (10.1016/j.toxlet.2008.06.861_bib37) 1993; 14 Brustovetsky (10.1016/j.toxlet.2008.06.861_bib8) 2000; 20 Kuhlmann (10.1016/j.toxlet.2008.06.861_bib25) 1998; 29 Merfort (10.1016/j.toxlet.2008.06.861_bib34) 1996; 62 Galati (10.1016/j.toxlet.2008.06.861_bib16) 2006; 40 Mani (10.1016/j.toxlet.2008.06.861_bib32) 2003; 374 Larche (10.1016/j.toxlet.2008.06.861_bib27) 2006; 48 Navas (10.1016/j.toxlet.2008.06.861_bib35) 1955; 10 Piel (10.1016/j.toxlet.2008.06.861_bib38) 2007; 35 Shen (10.1016/j.toxlet.2008.06.861_bib43) 1984; 785 Gerasimenko (10.1016/j.toxlet.2008.06.861_bib18) 2002; 115 Kambayashi (10.1016/j.toxlet.2008.06.861_bib21) 2003; 28 Tampo (10.1016/j.toxlet.2008.06.861_bib44) 1998; 430 Mayrand (10.1016/j.toxlet.2008.06.861_bib33) 1982; 16 Khodakova (10.1016/j.toxlet.2008.06.861_bib23) 2007; 11 Kushnareva (10.1016/j.toxlet.2008.06.861_bib26) 2005; 280 Schmidt (10.1016/j.toxlet.2008.06.861_bib42) 2008; 23 Criddle (10.1016/j.toxlet.2008.06.861_bib11) 2006; 281 Crouser (10.1016/j.toxlet.2008.06.861_bib12) 2004; 4 Sarkissian (10.1016/j.toxlet.2008.06.861_bib40) 2000; 280 Chernyak (10.1016/j.toxlet.2008.06.861_bib10) 1995; 365 Henry (10.1016/j.toxlet.2008.06.861_bib19) 1995; 45 Scalbert (10.1016/j.toxlet.2008.06.861_bib41) 2000; 130 Levy (10.1016/j.toxlet.2008.06.861_bib29) 2007; 35 Wayne (10.1016/j.toxlet.2008.06.861_bib46) 1980; 11 Aura (10.1016/j.toxlet.2008.06.861_bib2) 2002; 50 Chance (10.1016/j.toxlet.2008.06.861_bib9) 1955; 217 Oberholzer (10.1016/j.toxlet.2008.06.861_bib36) 2001; 15 Toninello (10.1016/j.toxlet.2008.06.861_bib45) 2004; 37 Limasset (10.1016/j.toxlet.2008.06.861_bib31) 1999; 65 Déprez (10.1016/j.toxlet.2008.06.861_bib13) 2000; 130 Jenner (10.1016/j.toxlet.2008.06.861_bib20) 2005; 38 Deutsch (10.1016/j.toxlet.2008.06.861_bib14) 1997; 690 Karlsson (10.1016/j.toxlet.2008.06.861_bib22) 2005; 135 Beloborodova (10.1016/j.toxlet.2008.06.861_bib4) 2006; 2 |
References_xml | – volume: 14 start-page: 749 year: 1991 end-page: 754 ident: bib1 article-title: Content of phenylalanine, tyrosine and their metabolites in CSF in phenylketonuria publication-title: J. Inherit. Metab. Dis. contributor: fullname: Railian – volume: 40 start-page: 570 year: 2006 end-page: 580 ident: bib16 article-title: Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins publication-title: Free Radic. Biol. Med. contributor: fullname: O’Brien – volume: 280 start-page: 28894 year: 2005 end-page: 28902 ident: bib26 article-title: Excitotoxic injury to mitochondria isolated from cultured neurons publication-title: J. Biol. Chem. contributor: fullname: Murphy – volume: 23 start-page: 65 year: 2008 end-page: 71 ident: bib42 article-title: The uraemic toxin phenylacetic acid increases the formation of reactive oxygen species in vascular smooth muscle cells publication-title: Neprol. Dial. Transplant. contributor: fullname: van der Giet – volume: 20 start-page: 103 year: 2000 end-page: 113 ident: bib8 article-title: Dual responses of CNS mitochondria to elevated calcium publication-title: J. Neurosci. contributor: fullname: Dubinsky – volume: 785 start-page: 181 year: 1984 end-page: 185 ident: bib43 article-title: Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver publication-title: Biochim. Biophys. Acta contributor: fullname: Shen – volume: 5 start-page: 365 year: 2003 end-page: 371 ident: bib5 article-title: Mitochondrial Dysfunction in Sepsis publication-title: Curr. Infect. Dis. Rep. contributor: fullname: Singer – volume: 35 start-page: 2150 year: 2007 end-page: 2155 ident: bib39 article-title: Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle publication-title: Crit. Care Med. contributor: fullname: Singer – volume: 135 start-page: 2343 year: 2005 end-page: 2349 ident: bib22 article-title: Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds publication-title: J. Nutr. contributor: fullname: Rafter – volume: 37 start-page: 1073 year: 2004 end-page: 1080 ident: bib45 article-title: Menadione induces a low conductance state of the mitochondrial inner membrane sensitive to bongkrekic acid publication-title: Free Radic. Biol. Med. contributor: fullname: Richter – volume: 690 start-page: 1 year: 1997 end-page: 6 ident: bib14 article-title: Determination of publication-title: Chromatogr. B Biomed. Sci. Appl. contributor: fullname: Deutsch – volume: 28 start-page: 24 year: 2007 end-page: 28 ident: bib28 article-title: Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis publication-title: Shock contributor: fullname: Levy – volume: 11 start-page: 743 year: 1980 end-page: 745 ident: bib46 article-title: Production of phenylacetic and hydroxyphenylacetic acids by clostridium botulinum type G publication-title: J. Clin. Microb. contributor: fullname: Mccroskey – volume: 65 start-page: 23 year: 1999 end-page: 29 ident: bib31 article-title: Inhibition of chemiluminescence in human PMNs by monocyclic phenolic acids and flavonoids publication-title: Planta Med. contributor: fullname: Doré – volume: 28 start-page: 139 year: 2003 end-page: 148 ident: bib21 article-title: Reestimation of Cypridina luciferin analogs (MCLA) as a chemiluminescence probe to detect active oxygen species—cautionary note for use of MCLA publication-title: J Toxicol. Sci. contributor: fullname: Ogino – volume: 62 start-page: 289 year: 1996 end-page: 292 ident: bib34 article-title: Radical scavenger activity of three flavonoid metabolites studied by inhibition of chemiluminescence in human PMNs publication-title: Planta Med. contributor: fullname: Gardana – volume: 14 start-page: 217 year: 1993 end-page: 223 ident: bib37 article-title: Detection of H publication-title: Free Radic. Biol. Med. contributor: fullname: Freeman – volume: 4 start-page: 729 year: 2004 end-page: 741 ident: bib12 article-title: Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome publication-title: Mitochondrion contributor: fullname: Crouser – volume: 365 start-page: 75 year: 1995 end-page: 78 ident: bib10 article-title: Ca(2 publication-title: FEBS Lett. contributor: fullname: Chernyak – volume: 50 start-page: 1725 year: 2002 end-page: 1730 ident: bib2 article-title: Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro publication-title: J. Agric. Food Chem. contributor: fullname: Poutanen – volume: 281 start-page: 40485 year: 2006 end-page: 40492 ident: bib11 article-title: Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells publication-title: J. Biol. Chem. contributor: fullname: Petersen – volume: 35 start-page: S468 year: 2007 end-page: 475 ident: bib29 article-title: Cytochrome c oxidase dysfunction in sepsis publication-title: Crit. Care Med. contributor: fullname: Deutschman – volume: 374 start-page: 521 year: 2003 end-page: 527 ident: bib32 article-title: Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine publication-title: Biochem. J. contributor: fullname: Moore – volume: 10 start-page: 1150 year: 2004 end-page: 1159 ident: bib30 article-title: Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells publication-title: Clin. Cancer Res. contributor: fullname: Lau – volume: 16 start-page: 747 year: 1982 end-page: 750 ident: bib33 article-title: Production of phenylacetic acid by anaerobes publication-title: J. Clin. Microb. contributor: fullname: Bourgeau – volume: 35 start-page: 2120 year: 2007 end-page: 2127 ident: bib38 article-title: Mitochondrial resuscitation with exogenous cytochrome c in the septic heart publication-title: Crit. Care Med. contributor: fullname: Levy – volume: 41 start-page: 56 year: 2006 end-page: 64 ident: bib15 article-title: Nonenzymatic formation of succinate in mitochondria under oxidative stress publication-title: Free Radic. Biol. Med. contributor: fullname: Kondrashova – volume: 1/3 start-page: 249 year: 2001 end-page: 267 ident: bib24 article-title: Preservation of native properties of mitochondria in rat liver homogenate publication-title: Mitochondrion contributor: fullname: Temnov – volume: 29 start-page: 451 year: 1998 end-page: 460 ident: bib25 article-title: Inhibition of oxidant-induced lipid peroxidation in cultured renal tubular epithelial cells (LLC-PK1) by quercetin publication-title: Free Radic. Res. contributor: fullname: Köhler – volume: 11 start-page: P5 year: 2007 ident: bib23 article-title: Microbial metabolites in the blood of patients with sepsis publication-title: Crit. l Care. contributor: fullname: Beloborodova – volume: 286 start-page: R491 year: 2004 end-page: 497 ident: bib7 article-title: Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. contributor: fullname: Singer – volume: 130 start-page: 2073S year: 2000 end-page: 2085S ident: bib41 article-title: Dietary intake and bioavailability of polyphenols publication-title: J. Nutr. contributor: fullname: Williamson – volume: 45 start-page: 489 year: 1995 end-page: 504 ident: bib19 article-title: Channel-specific induction of the cyclosporine A-sensitive mitochondrial permeability transition by menadione publication-title: J. Toxicol. Environ. Health contributor: fullname: Wallace – volume: 280 start-page: 242 year: 2000 end-page: 249 ident: bib40 article-title: Measurement of phenyllactate, phenylacetate, and phenylpyruvate by negative ion chemical ionization-gas chromatography/mass spectrometry in brain of mouse genetic models of phenylketonuria and non-phenylketonuria hyperphenylalaninemia publication-title: Anal. Biochem. contributor: fullname: Mamer – volume: 430 start-page: 348 year: 1998 end-page: 352 ident: bib44 article-title: The antioxidant action of 2-methyl-6-( publication-title: FEBS Lett. contributor: fullname: Yonaha – volume: 360 start-page: 219 year: 2002 end-page: 223 ident: bib6 article-title: Association between mitochondrial dysfunction and severity and outcome of septic shock publication-title: Lancet contributor: fullname: Singer – volume: 10 start-page: 175 year: 1955 end-page: 184 ident: bib35 article-title: Enhancement and inhibition of luminol chemiluminescence by phenolic acids publication-title: J. Biolumin. Chemilumin contributor: fullname: González – volume: 48 start-page: 377 year: 2006 end-page: 385 ident: bib27 article-title: Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality publication-title: J. Am. Coll. Cardiol. contributor: fullname: Neviere – volume: 217 start-page: 383 year: 1955 end-page: 393 ident: bib9 article-title: Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization publication-title: J. Biol. Chem. contributor: fullname: Williams – volume: 12 start-page: 12 year: 2000 end-page: 21 ident: bib3 article-title: Small molecules originating from microbes (SMOM) and their role in microbes-host relationship publication-title: Microbial ecology in Health and Disease contributor: fullname: Osipov – volume: 38 start-page: 763 year: 2005 end-page: 772 ident: bib20 article-title: Human fecal water content of phenolics: The extent of colonic exposure to phenolic compounds publication-title: Free Radic. Biol. Med. contributor: fullname: Halliwell – volume: 64 start-page: 517 year: 1992 end-page: 522 ident: bib17 article-title: Hematin as a peroxidase substitute in hydrogen peroxide determinations publication-title: Anal. Chem. contributor: fullname: Dasgupta – volume: 115 start-page: 485 year: 2002 end-page: 497 ident: bib18 article-title: Menadione-induced apoptosis: roles of cytosolic Ca(2 publication-title: J. Cell Sci. contributor: fullname: Watson – volume: 2 start-page: 3 year: 2006 end-page: 6 ident: bib4 article-title: Chromatography-mass spectrometric detection of low-molecular-weight phenolic compounds originating from microbes in the serum from patients with sepsis (Rus) publication-title: Klin. Lab. Diagn. contributor: fullname: Olenin – volume: 15 start-page: 879 year: 2001 end-page: 892 ident: bib36 article-title: Apoptosis in sepsis: a new target for therapeutic exploration publication-title: FASEB J. contributor: fullname: Moldawer – volume: 130 start-page: 2733 year: 2000 end-page: 2738 ident: bib13 article-title: Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids publication-title: J. Nutr. contributor: fullname: Scalbert – volume: 12 start-page: 12 year: 2000 ident: 10.1016/j.toxlet.2008.06.861_bib3 article-title: Small molecules originating from microbes (SMOM) and their role in microbes-host relationship publication-title: Microbial ecology in Health and Disease doi: 10.1080/089106000435545 contributor: fullname: Beloborodova – volume: 365 start-page: 75 year: 1995 ident: 10.1016/j.toxlet.2008.06.861_bib10 article-title: Ca(2+)-triggered membrane permeability transition in de-energized mitochondria from rat liver publication-title: FEBS Lett. doi: 10.1016/0014-5793(95)00411-2 contributor: fullname: Chernyak – volume: 11 start-page: P5 issue: Suppl 4 year: 2007 ident: 10.1016/j.toxlet.2008.06.861_bib23 article-title: Microbial metabolites in the blood of patients with sepsis publication-title: Crit. l Care. doi: 10.1186/cc5984 contributor: fullname: Khodakova – volume: 14 start-page: 217 year: 1993 ident: 10.1016/j.toxlet.2008.06.861_bib37 article-title: Detection of H2O2 release from vascular endothelial cells publication-title: Free Radic. Biol. Med. doi: 10.1016/0891-5849(93)90013-K contributor: fullname: Panus – volume: 280 start-page: 242 year: 2000 ident: 10.1016/j.toxlet.2008.06.861_bib40 article-title: Measurement of phenyllactate, phenylacetate, and phenylpyruvate by negative ion chemical ionization-gas chromatography/mass spectrometry in brain of mouse genetic models of phenylketonuria and non-phenylketonuria hyperphenylalaninemia publication-title: Anal. Biochem. doi: 10.1006/abio.2000.4542 contributor: fullname: Sarkissian – volume: 37 start-page: 1073 year: 2004 ident: 10.1016/j.toxlet.2008.06.861_bib45 article-title: Menadione induces a low conductance state of the mitochondrial inner membrane sensitive to bongkrekic acid publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2004.06.044 contributor: fullname: Toninello – volume: 2 start-page: 3 year: 2006 ident: 10.1016/j.toxlet.2008.06.861_bib4 article-title: Chromatography-mass spectrometric detection of low-molecular-weight phenolic compounds originating from microbes in the serum from patients with sepsis (Rus) publication-title: Klin. Lab. Diagn. contributor: fullname: Beloborodova – volume: 62 start-page: 289 year: 1996 ident: 10.1016/j.toxlet.2008.06.861_bib34 article-title: Radical scavenger activity of three flavonoid metabolites studied by inhibition of chemiluminescence in human PMNs publication-title: Planta Med. doi: 10.1055/s-2006-957886 contributor: fullname: Merfort – volume: 28 start-page: 139 year: 2003 ident: 10.1016/j.toxlet.2008.06.861_bib21 article-title: Reestimation of Cypridina luciferin analogs (MCLA) as a chemiluminescence probe to detect active oxygen species—cautionary note for use of MCLA publication-title: J Toxicol. Sci. doi: 10.2131/jts.28.139 contributor: fullname: Kambayashi – volume: 785 start-page: 181 year: 1984 ident: 10.1016/j.toxlet.2008.06.861_bib43 article-title: Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver publication-title: Biochim. Biophys. Acta doi: 10.1016/0167-4838(84)90142-0 contributor: fullname: Shen – volume: 35 start-page: 2120 year: 2007 ident: 10.1016/j.toxlet.2008.06.861_bib38 article-title: Mitochondrial resuscitation with exogenous cytochrome c in the septic heart publication-title: Crit. Care Med. doi: 10.1097/01.CCM.0000278914.85340.FE contributor: fullname: Piel – volume: 16 start-page: 747 year: 1982 ident: 10.1016/j.toxlet.2008.06.861_bib33 article-title: Production of phenylacetic acid by anaerobes publication-title: J. Clin. Microb. doi: 10.1128/JCM.16.4.747-750.1982 contributor: fullname: Mayrand – volume: 45 start-page: 489 year: 1995 ident: 10.1016/j.toxlet.2008.06.861_bib19 article-title: Channel-specific induction of the cyclosporine A-sensitive mitochondrial permeability transition by menadione publication-title: J. Toxicol. Environ. Health doi: 10.1080/15287399509532011 contributor: fullname: Henry – volume: 4 start-page: 729 year: 2004 ident: 10.1016/j.toxlet.2008.06.861_bib12 article-title: Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome publication-title: Mitochondrion doi: 10.1016/j.mito.2004.07.023 contributor: fullname: Crouser – volume: 130 start-page: 2733 year: 2000 ident: 10.1016/j.toxlet.2008.06.861_bib13 article-title: Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids publication-title: J. Nutr. doi: 10.1093/jn/130.11.2733 contributor: fullname: Déprez – volume: 11 start-page: 743 year: 1980 ident: 10.1016/j.toxlet.2008.06.861_bib46 article-title: Production of phenylacetic and hydroxyphenylacetic acids by clostridium botulinum type G publication-title: J. Clin. Microb. doi: 10.1128/JCM.11.6.743-745.1980 contributor: fullname: Wayne – volume: 23 start-page: 65 year: 2008 ident: 10.1016/j.toxlet.2008.06.861_bib42 article-title: The uraemic toxin phenylacetic acid increases the formation of reactive oxygen species in vascular smooth muscle cells publication-title: Neprol. Dial. Transplant. doi: 10.1093/ndt/gfm475 contributor: fullname: Schmidt – volume: 50 start-page: 1725 year: 2002 ident: 10.1016/j.toxlet.2008.06.861_bib2 article-title: Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro publication-title: J. Agric. Food Chem. doi: 10.1021/jf0108056 contributor: fullname: Aura – volume: 20 start-page: 103 year: 2000 ident: 10.1016/j.toxlet.2008.06.861_bib8 article-title: Dual responses of CNS mitochondria to elevated calcium publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.20-01-00103.2000 contributor: fullname: Brustovetsky – volume: 40 start-page: 570 year: 2006 ident: 10.1016/j.toxlet.2008.06.861_bib16 article-title: Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2005.09.014 contributor: fullname: Galati – volume: 430 start-page: 348 year: 1998 ident: 10.1016/j.toxlet.2008.06.861_bib44 article-title: The antioxidant action of 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-alPhA]pyrazin-3-one (MCLA), a chemiluminescence probe to detect superoxide anions publication-title: FEBS Lett. doi: 10.1016/S0014-5793(98)00689-9 contributor: fullname: Tampo – volume: 280 start-page: 28894 year: 2005 ident: 10.1016/j.toxlet.2008.06.861_bib26 article-title: Excitotoxic injury to mitochondria isolated from cultured neurons publication-title: J. Biol. Chem. doi: 10.1074/jbc.M503090200 contributor: fullname: Kushnareva – volume: 217 start-page: 383 year: 1955 ident: 10.1016/j.toxlet.2008.06.861_bib9 article-title: Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)57189-7 contributor: fullname: Chance – volume: 1/3 start-page: 249 year: 2001 ident: 10.1016/j.toxlet.2008.06.861_bib24 article-title: Preservation of native properties of mitochondria in rat liver homogenate publication-title: Mitochondrion doi: 10.1016/S1567-7249(01)00025-3 contributor: fullname: Kondrashova – volume: 5 start-page: 365 year: 2003 ident: 10.1016/j.toxlet.2008.06.861_bib5 article-title: Mitochondrial Dysfunction in Sepsis publication-title: Curr. Infect. Dis. Rep. doi: 10.1007/s11908-003-0015-9 contributor: fullname: Brealey – volume: 64 start-page: 517 year: 1992 ident: 10.1016/j.toxlet.2008.06.861_bib17 article-title: Hematin as a peroxidase substitute in hydrogen peroxide determinations publication-title: Anal. Chem. doi: 10.1021/ac00029a013 contributor: fullname: Genfa – volume: 374 start-page: 521 issue: Pt 2 year: 2003 ident: 10.1016/j.toxlet.2008.06.861_bib32 article-title: Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine publication-title: Biochem. J. doi: 10.1042/bj20030670 contributor: fullname: Mani – volume: 360 start-page: 219 year: 2002 ident: 10.1016/j.toxlet.2008.06.861_bib6 article-title: Association between mitochondrial dysfunction and severity and outcome of septic shock publication-title: Lancet doi: 10.1016/S0140-6736(02)09459-X contributor: fullname: Brealey – volume: 38 start-page: 763 year: 2005 ident: 10.1016/j.toxlet.2008.06.861_bib20 article-title: Human fecal water content of phenolics: The extent of colonic exposure to phenolic compounds publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2004.11.020 contributor: fullname: Jenner – volume: 35 start-page: 2150 year: 2007 ident: 10.1016/j.toxlet.2008.06.861_bib39 article-title: Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle publication-title: Crit. Care Med. doi: 10.1097/01.ccm.0000281448.00095.4d contributor: fullname: Protti – volume: 135 start-page: 2343 year: 2005 ident: 10.1016/j.toxlet.2008.06.861_bib22 article-title: Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds publication-title: J. Nutr. doi: 10.1093/jn/135.10.2343 contributor: fullname: Karlsson – volume: 690 start-page: 1 year: 1997 ident: 10.1016/j.toxlet.2008.06.861_bib14 article-title: Determination of p-hydroxyphenylpyruvate, p-hydroxyphenyllactate and tyrosine in normal human plasma by gas chromatography–mass spectrometry isotope-dilution assay publication-title: Chromatogr. B Biomed. Sci. Appl. doi: 10.1016/S0378-4347(96)00411-2 contributor: fullname: Deutsch – volume: 65 start-page: 23 year: 1999 ident: 10.1016/j.toxlet.2008.06.861_bib31 article-title: Inhibition of chemiluminescence in human PMNs by monocyclic phenolic acids and flavonoids publication-title: Planta Med. doi: 10.1055/s-1999-13956 contributor: fullname: Limasset – volume: 48 start-page: 377 year: 2006 ident: 10.1016/j.toxlet.2008.06.861_bib27 article-title: Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2006.02.069 contributor: fullname: Larche – volume: 10 start-page: 1150 year: 2004 ident: 10.1016/j.toxlet.2008.06.861_bib30 article-title: Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-0747-3 contributor: fullname: Li – volume: 115 start-page: 485 issue: Pt 3 year: 2002 ident: 10.1016/j.toxlet.2008.06.861_bib18 article-title: Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore publication-title: J. Cell Sci. doi: 10.1242/jcs.115.3.485 contributor: fullname: Gerasimenko – volume: 286 start-page: R491 year: 2004 ident: 10.1016/j.toxlet.2008.06.861_bib7 article-title: Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol. doi: 10.1152/ajpregu.00432.2003 contributor: fullname: Brealey – volume: 35 start-page: S468 issue: 9 Suppl. year: 2007 ident: 10.1016/j.toxlet.2008.06.861_bib29 article-title: Cytochrome c oxidase dysfunction in sepsis publication-title: Crit. Care Med. doi: 10.1097/01.CCM.0000278604.93569.27 contributor: fullname: Levy – volume: 15 start-page: 879 year: 2001 ident: 10.1016/j.toxlet.2008.06.861_bib36 article-title: Apoptosis in sepsis: a new target for therapeutic exploration publication-title: FASEB J. doi: 10.1096/fj.00-058rev contributor: fullname: Oberholzer – volume: 14 start-page: 749 year: 1991 ident: 10.1016/j.toxlet.2008.06.861_bib1 article-title: Content of phenylalanine, tyrosine and their metabolites in CSF in phenylketonuria publication-title: J. Inherit. Metab. Dis. doi: 10.1007/BF01799945 contributor: fullname: Antoshechkin – volume: 130 start-page: 2073S year: 2000 ident: 10.1016/j.toxlet.2008.06.861_bib41 article-title: Dietary intake and bioavailability of polyphenols publication-title: J. Nutr. doi: 10.1093/jn/130.8.2073S contributor: fullname: Scalbert – volume: 281 start-page: 40485 year: 2006 ident: 10.1016/j.toxlet.2008.06.861_bib11 article-title: Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M607704200 contributor: fullname: Criddle – volume: 41 start-page: 56 year: 2006 ident: 10.1016/j.toxlet.2008.06.861_bib15 article-title: Nonenzymatic formation of succinate in mitochondria under oxidative stress publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2006.02.012 contributor: fullname: Fedotcheva – volume: 28 start-page: 24 year: 2007 ident: 10.1016/j.toxlet.2008.06.861_bib28 article-title: Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis publication-title: Shock doi: 10.1097/01.shk.0000235089.30550.2d contributor: fullname: Levy – volume: 29 start-page: 451 year: 1998 ident: 10.1016/j.toxlet.2008.06.861_bib25 article-title: Inhibition of oxidant-induced lipid peroxidation in cultured renal tubular epithelial cells (LLC-PK1) by quercetin publication-title: Free Radic. Res. doi: 10.1080/10715769800300501 contributor: fullname: Kuhlmann – volume: 10 start-page: 175 year: 1955 ident: 10.1016/j.toxlet.2008.06.861_bib35 article-title: Enhancement and inhibition of luminol chemiluminescence by phenolic acids publication-title: J. Biolumin. Chemilumin contributor: fullname: Navas |
SSID | ssj0006465 |
Score | 2.1335707 |
Snippet | Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionаte,
р-hydroxyphenyllactate, and
p-hydroxyphenylacetate are essentially... Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionate, p-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially... Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropion?te, ?-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 182 |
SubjectTerms | Adenosine Diphosphate - metabolism Animals Bacteria - chemistry Cyclosporine - pharmacology Electron Transport - drug effects Hydroxybenzoates - chemistry Hydroxybenzoates - toxicity Male Membrane Potentials - drug effects Mitochondria - drug effects Mitochondrial dysfunction Oxygen Consumption - drug effects Phenolic acids Rats Reactive Oxygen Species ROS Sepsis Structure-Activity Relationship Vitamin K 3 - pharmacology |
Title | Toxic effects of microbial phenolic acids on the functions of mitochondria |
URI | https://dx.doi.org/10.1016/j.toxlet.2008.06.861 https://www.ncbi.nlm.nih.gov/pubmed/18634861 https://search.proquest.com/docview/20962604 |
Volume | 180 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB50vQgivl2fOYgn626bNEmPy6KsiiK4grfSNCmsYCvahfXib3fSpC4eRPDYNqFhZvrNTPrNBOCEqyIxSUEDERmDCYrSgcpyFehCS2EwQuANieb2jo8e2fVT_LQAw7YWxtIqPfY7TG_Q2t_peWn2XieT3kOfCskwqcKYJ-zTWCzCErojxjqwNLi6Gd19AzJnzYmSdnxgJ7QVdA3Nq65mKCBPquTnkoe_eajfItDGE12uwaoPIcnArXIdFky5Aaf3rgf1xxkZz0uq3s_IKbmfd6f-2IAVt1FHXP3RJlyPqxleel4HqQryMmmaM-ErLP_L9g0mWT7R-KwkGC4S6woba3WD6woRtNRoyFvweHkxHo4Cf8BCkNMkrANVZGEUSRPTWOV205JGom90bLRkVKhYhybLTKx4JnARWnLb3i5kkdKKFjEzdBs6ZVWaXSCaSZrznFKb4kSMSqMFF7xgXCdSi7wLQSvU9NX10Uhbgtlz6pTgj8TkKSqhC6KVfPrDHlKE-j9mHreKSvFTsf8_stJU03cclNj0jXVhx-lvvhLJKcO5e_9-6z4sOyYJ4o48gE79NjWHGK7U6ggWzz_DI2-UXzhu6vs |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB7W9aAg4tv1mYN42u5umzRJjyIu6xPBFbyVpkmhgq1oBffib3fStCweRPDYdkLDzHTyTfrNBOCEqywyUUY9ERiDCYrSnkpS5elMS2EQIfCaRHN7xyeP7OopfOrAeVsLY2mVTex3Mb2O1s2dYaPN4WueDx9GVEiGSRViHn9EQ7EAixYNWF7X4GvO8-CsPk_SSntWvK2fq0leVfmJ6mkolXwguf_b-vQb_qzXofEarDYAkpy5Oa5DxxQbcHrvOlDP-mQ6L6h675NTcj_vTT3bgBW3TUdc9dEmXE3LT7xsWB2kzMhLXrdmwldY9pftGkySNNf4rCAIFoldCGtfdcJVifGz0OjGW_A4vpieT7zmeAUvpZFfeSpL_CCQJqShSu2WJQ3EyOjQaMmoUKH2TZKYUPFE4CS05La5nc8CpRXNQmboNnSLsjC7QDSTNOUppTbBCRiVRgsueMa4jqQWaQ-8Vqnxq-uiEbf0sufYGaE5EJPHaIQeiFbz8Q9viDHQ_zHyuDVUjB-K_fuRFKb8eEehyCZvrAc7zn7zmUhOGY7d-_dbj2FpMr29iW8u7673YdlxSjACyQPoVm8f5hCBS6WOasf8Bk5j69A |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Toxic+effects+of+microbial+phenolic+acids+on+the+functions+of+mitochondria&rft.jtitle=Toxicology+letters&rft.au=Fedotcheva%2C+N+I&rft.au=Kazakov%2C+R+E&rft.au=Kondrashova%2C+M+N&rft.au=Beloborodova%2C+N+V&rft.date=2008-08-28&rft.issn=0378-4274&rft.volume=180&rft.issue=3&rft.spage=182&rft_id=info:doi/10.1016%2Fj.toxlet.2008.06.861&rft_id=info%3Apmid%2F18634861&rft.externalDocID=18634861 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0378-4274&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0378-4274&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0378-4274&client=summon |