Continuous nicotine infusion reduces nicotine self-administration in rats with 23-h/day access to nicotine

• Published in: Pharmacology, biochemistry and behavior Vol. 72; no. 1; pp. 279 - 289
• Main Authors: LeSage, Mark G., Keyler, Dan E., Shoeman, Don, Raphael, Donna, Collins, Gregory, Pentel, Paul R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2002; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Conditioning, Operant - drug effects; Conditioning, Operant - physiology; Dose-Response Relationship, Drug; Infusions, Intravenous; Male; Medical sciences; Nicotine; Nicotine - administration & dosage; Nicotine - blood; Nicotine concentrations; Nicotine replacement therapy; Rats; Rats, Sprague-Dawley; Reaction Time - drug effects; Reaction Time - physiology; Self Administration - methods; Self Administration - psychology; Self-administration; Time Factors; Tobacco, tobacco smoking; Toxicology; Self-administration; Nicotine concentrations; Nicotine replacement therapy; Nicotine; Replacement therapy; Rat; Continuous; Rodentia; Tobacco smoking; Self administration; Vertebrata; Alkaloid; Mammalia; Animal; Subcutaneous administration

The effects of continuous nicotine infusion on nicotine self-administration (NSA) were studied in rats as a model of nicotine replacement therapy (NRT) in humans. A NSA model in which rats had 23-h/day access to nicotine was used to approximate nicotine access conditions in cigarette smokers. In ord...