Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTD

• Published in: Neurology Vol. 77; no. 9; p. 866
• Main Authors: Whitwell, J L, Josephs, K A, Avula, R, Tosakulwong, N, Weigand, S D, Senjem, M L, Vemuri, P, Jones, D T, Gunter, J L, Baker, M, Wszolek, Z K, Knopman, D S, Rademakers, R, Petersen, R C, Boeve, B F, Jack, Jr, C R
• Format: Journal Article
• Language: English
• Published: United States 30.08.2011
• Subjects: Adult; Aged; Case-Control Studies; Cerebral Cortex - physiology; Cerebral Cortex - physiopathology; Female; Frontotemporal Dementia - genetics; Frontotemporal Dementia - physiopathology; Frontotemporal Dementia - psychology; Humans; Male; Middle Aged; Mutation - genetics; Nerve Net - physiology; Nerve Net - physiopathology; Social Behavior; tau Proteins - genetics; Young Adult

To determine whether functional connectivity is altered in subjects with mutations in the microtubule associated protein tau (MAPT) gene who were asymptomatic but were destined to develop dementia, and to compare these findings to those in subjects with behavioral variant frontotemporal dementia (bv...