Identification and overexpression of human neutrophil α-defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue

• Published in: Oral oncology Vol. 40; no. 2; pp. 139 - 144
• Main Authors: Lundy, Fionnuala T., Orr, David F., Gallagher, James R., Maxwell, Perry, Shaw, Chris, Napier, Seamus S., Gerald Cowan, C., Lamey, Philip-John, Marley, John J.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.2004; Elsevier
• Subjects: Adult; alpha-Defensins - metabolism; Amino Acid Sequence; Biological and medical sciences; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Chromatography, High Pressure Liquid; Defensin; Female; Human; Humans; Male; Medical sciences; Middle Aged; Molecular Sequence Data; Neoplasm Proteins - metabolism; Neoplasm Staging; Oral cancer; Otorhinolaryngology. Stomatology; Proteomics; Tongue Neoplasms - metabolism; Tongue Neoplasms - pathology; Tumors; Tumour; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Human; OSCC; Oral cancer; Matrix assisted laser desorption ionisation mass spectrometry; MALDI-MS; 2D-PAGE; 2-dimensional polyacrylamide gel electrophoresis; HNP; Oral squamous cell carcinoma; High pressure liquid chromatography; Proteomics; Tumour; Human defensin; Defensin; HD; HPLC; Human neutrophil peptide; Squamous cell carcinoma; Tongue; Peptides; Stomatology; Granulocyte; ENT; Malignant tumor; Cancerology; Oral cavity disease; Neutrophil

To date, little attention has been paid to the possible role of α-defensins (human neutrophil peptides 1-3), HNP-1, HNP-2 and HNP-3 in innate host defence against tumour invasion. In the current study, using a single-dimensional high pressure liquid chromatography (HPLC) method for peptide separatio...