The loss of susceptibility to apoptosis in exudated tissue neutrophils is associated with their nuclear factor-κB activation

• Published in: European journal of pharmacology Vol. 433; no. 1; pp. 17 - 27
• Main Authors: Hotta, Koichi, Niwa, Masayuki, Hara, Akira, Ohno, Takatoshi, Wang, Xiaodan, Matsuno, Hiroyuki, Kozawa, Osamu, Ito, Hidenori, Kato, Kanefusa, Otsuka, Takanobu, Matsui, Nobuo, Uematsu, Toshihiko
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 14.12.2001; Elsevier
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Caspase 3; Caspases - metabolism; circulating blood; Cyclophosphamide - pharmacology; DNA Fragmentation; Enzyme Activation; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunobiology; Inflammation; Miscellaneous; Molecular and cellular biology; Neutrophil; Neutrophils - drug effects; Neutrophils - physiology; NF-kappa B - physiology; Regulatory factors and their cellular receptors; Superoxides - metabolism; tissue; Transcription factor; Tumor Necrosis Factor-alpha - pharmacology; Transcription factor; Neutrophil; Apoptosis; Human; Immunopathology; Biological fluid; Healthy subject; Diseases of the osteoarticular system; Tissue specificity; Autoimmune disease; Inflammatory joint disease; Cellular immunity; Inflammation; In vitro; Biological activity; Blood; Synovial fluid; Chronic; Cell death; Rheumatoid arthritis; Defense mechanism; Transcription factor NFκB; Mechanism of action; Saliva; Tumor necrosis factor α

Tissue neutrophils, human salivary neutrophils donated from healthy subjects and synovial fluid neutrophils collected from patients with rheumatoid arthritis were compared with circulating blood neutrophils. Concomitant treatment of circulating blood neutrophils with tumor necrosis factor-α (TNF-α)...