Immunization against exon 1 decapeptides from the lutropin/choriogonadotropin receptor or the follitropin receptor as potential male contraceptive

• Published in: Journal of reproductive immunology Vol. 32; no. 1; pp. 37 - 54
• Main Authors: Remy, Jean-Jacques, Couture, Laurence, Rabesona, Hanitra, Haertle, Thomas, Salesse, Roland
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.11.1996
• Subjects: Amino Acid Sequence; Animals; Anti-receptor immunization; Chorionic Gonadotropin - immunology; Chorionic Gonadotropin - metabolism; Contraceptive Agents, Male - administration & dosage; Contraceptive Agents, Male - immunology; Contraceptive Agents, Male - pharmacology; Exons - immunology; Humans; Immune Sera - biosynthesis; Injections, Intraperitoneal; Injections, Subcutaneous; Lutropin and follitropin receptors; Male; Male contraceptive vaccine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oligopeptides - administration & dosage; Oligopeptides - immunology; Receptors, FSH - immunology; Receptors, LH - immunology; Testosterone - blood; Thyroid Hormones - blood; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Vaccines, Synthetic - pharmacology; Lutropin and follitropin receptors; Male contraceptive vaccine; Anti-receptor immunization

Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroidogenesis and gametogenesis in male and female gonads through interaction with G protein-coupled receptors, LHR and FSHR. In the male, LH acts on Leydig cells and is mostly responsible for the acquisition of puberty an...