Immunization against exon 1 decapeptides from the lutropin/choriogonadotropin receptor or the follitropin receptor as potential male contraceptive
Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroidogenesis and gametogenesis in male and female gonads through interaction with G protein-coupled receptors, LHR and FSHR. In the male, LH acts on Leydig cells and is mostly responsible for the acquisition of puberty an...
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Published in | Journal of reproductive immunology Vol. 32; no. 1; pp. 37 - 54 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
01.11.1996
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Abstract | Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroidogenesis and gametogenesis in male and female gonads through interaction with G protein-coupled receptors, LHR and FSHR. In the male, LH acts on Leydig cells and is mostly responsible for the acquisition of puberty and the production of androgens while FSH, together with androgens, regulates spermatogenesis within Sertoli cells. We have engineered filamentous phages displaying mouse LHR and human FSHR decapeptides chosen in hormone binding regions. Peptides from both receptors displayed on phages belong either to the receptor specific exon 1 (amino acids 18–27) or to the homologous exon 4 (amino acids 98–107). Vaccination of prepubertal
BALB
c
male mice with hybrid phages using sub-cutaneous or intraperitoneal injections induced immunity against receptors. Anti-receptor immunization produced agonist or antagonist effects depending only on the circulating levels of the antibodies. Both anti-LHR and anti-FSHR vaccines induced efficient as well as reversible male contraception, through different mechanisms: targeting LH receptors inhibited or hyperstimulated Leydig cell testosterone production while targeting FSH receptors did not affect testosterone levels. |
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AbstractList | Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroidogenesis and gametogenesis in male and female gonads through interaction with G protein-coupled receptors, LHR and FSHR. In the male, LH acts on Leydig cells and is mostly responsible for the acquisition of puberty and the production of androgens while FSH, together with androgens, regulates spermatogenesis within Sertoli cells. We have engineered filamentous phages displaying mouse LHR and human FSHR decapeptides chosen in hormone binding regions. Peptides from both receptors displayed on phages belong either to the receptor specific exon 1 (amino acids 18–27) or to the homologous exon 4 (amino acids 98–107). Vaccination of prepubertal
BALB
c
male mice with hybrid phages using sub-cutaneous or intraperitoneal injections induced immunity against receptors. Anti-receptor immunization produced agonist or antagonist effects depending only on the circulating levels of the antibodies. Both anti-LHR and anti-FSHR vaccines induced efficient as well as reversible male contraception, through different mechanisms: targeting LH receptors inhibited or hyperstimulated Leydig cell testosterone production while targeting FSH receptors did not affect testosterone levels. Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroidogenesis and gametogenesis in male and female gonads through interaction with G protein-coupled receptors, LHR and FSHR. In the male, LH acts on leydig cells and is mostly responsible for the acquisition of puberty and the production of androgens while FSH, together with androgens, regulates spermatogenesis within Sertoli cells. We have engineered filamentous phages displaying mouse LHR and human FSHR decapeptides chosen in hormone binding regions. Peptides from both receptors displayed on phages belong either to the receptor specific exon 1 (amino acids 18-27) or to the homologous exon 4 (amino acids 98-107). Vaccination of prepubertal BALB/c male mice with hybrid phages using sub-cutaneous or intraperitoneal injections induced immunity against receptors. Anti-receptor immunization produced agonist or antagonist effects depending only on the circulating levels of the antibodies. Both anti-LHR and anti-FSHR vaccines induced efficient as well as reversible male contraception, through different mechanisms: targeting LH receptors inhibited or hyperstimulated Leydig cell testosterone production while targeting FSH receptors did not affect testosterone levels. Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroido-genesis and gametogenesis in male and female gonads through interaction with G protein- coupled receptors, LHR and FSHR. In the male, LH acts on Leydig cells and is mostly responsible for the acquisition of puberty and the production of androgens while FSH, together with androgens, regulates spermatogenesis within Sertoli cells. We have engineered filamentous phages displaying mouse LHR and human FSHR decapeptides chosen in hormone binding regions. Peptides from both receptors displayed on phages belong either to the receptor specific exon 1 (amino acids 18-27) or to the homologous exon 4 (amino acids 98-107). Vaccination of prepubertal BALB/c male mice with hybrid phages using sub-cutaneous or intraperitoneal injections induced immunity against receptors. Anti-receptor immunization produced agonist or antagonist effects depending only on the circulating levels of the antibodies. Both anti-LHR and anti-FSHR vaccines induced efficient as well as reversible male contraception, through different mechanisms: targeting LH receptors inhibited or hyperstimulated Leydig cell testosterone production while targeting FSH receptors did not affect testosterone levels. |
Author | Salesse, Roland Remy, Jean-Jacques Couture, Laurence Rabesona, Hanitra Haertle, Thomas |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8953519$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_4161_hv_27202 crossref_primary_10_1016_j_domaniend_2014_09_001 crossref_primary_10_1016_S0301_6226_99_00029_9 crossref_primary_10_1046_j_1439_0531_2002_00331_x crossref_primary_10_1111_j_1600_0897_2005_00285_x crossref_primary_10_1016_j_domaniend_2011_03_002 crossref_primary_10_1095_biolreprod_102_003699 crossref_primary_10_1097_00005392_200202000_00037 crossref_primary_10_1016_j_jri_2004_07_003 crossref_primary_10_2460_ajvr_2003_64_292 crossref_primary_10_1111_j_1747_0285_2008_00748_x crossref_primary_10_1016_j_peptides_2006_05_027 crossref_primary_10_1016_j_jri_2007_01_004 crossref_primary_10_1093_bmb_62_1_175 crossref_primary_10_1016_j_ygcen_2009_05_012 |
Cites_doi | 10.1126/science.2502842 10.1016/0165-0378(93)90042-G 10.1210/jc.80.1.46 10.1016/S0969-2126(00)00054-X 10.1093/hmg/4.8.1429 10.1016/1043-2760(94)00215-P 10.1038/369455a0 10.1084/jem.182.1.59 10.1677/jme.0.0160015 10.1016/0958-1669(91)90032-Z 10.1016/0092-8674(95)90275-9 10.1016/S0015-0282(16)58166-7 10.1016/S0969-2126(01)00222-2 10.1002/j.1460-2075.1991.tb07714.x 10.1016/0022-2836(91)90354-9 10.1016/0167-7799(94)90137-6 10.1038/365652a0 10.1016/S0969-2126(01)00272-6 10.1677/jme.0.0140051 |
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Keywords | Lutropin and follitropin receptors Male contraceptive vaccine Anti-receptor immunization |
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Snippet | Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroidogenesis and gametogenesis in male and female gonads through interaction... Pituitary gonadotropin hormones lutropin (LH) and follitropin (FSH) control steroido-genesis and gametogenesis in male and female gonads through interaction... |
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SubjectTerms | Amino Acid Sequence Animals Anti-receptor immunization Chorionic Gonadotropin - immunology Chorionic Gonadotropin - metabolism Contraceptive Agents, Male - administration & dosage Contraceptive Agents, Male - immunology Contraceptive Agents, Male - pharmacology Exons - immunology Humans Immune Sera - biosynthesis Injections, Intraperitoneal Injections, Subcutaneous Lutropin and follitropin receptors Male Male contraceptive vaccine Mice Mice, Inbred BALB C Molecular Sequence Data Oligopeptides - administration & dosage Oligopeptides - immunology Receptors, FSH - immunology Receptors, LH - immunology Testosterone - blood Thyroid Hormones - blood Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Vaccines, Synthetic - pharmacology |
Title | Immunization against exon 1 decapeptides from the lutropin/choriogonadotropin receptor or the follitropin receptor as potential male contraceptive |
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