NK1 tachykinin receptor antagonist treatment reduces cerebral edema and intracranial pressure in an ovine model of ischemic stroke - Sorby-Adams, Annabel J; Marian, Oana C; Bilecki, Isabella M; Elms, Levi E; Yassi, Nawaf; Hood, Rebecca J; Coller, Janet K; Stuckey, Shannon M; Kimberly, W Taylor; Farr, Tracy D; Leonard, Anna V; Thornton, Emma; et al. (Journal of cerebral blood flow and metabolism, 2024)
Keywords: Animals; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Brain Edema - drug therapy; Brain Edema - etiology; Disease Models, Animal; Female; Infarction, Middle Cerebral Artery - complications; Infarction, Middle Cerebral Artery - drug therapy; Intracranial Hypertension - drug therapy; Intracranial Hypertension - etiology; Intracranial Pressure - drug effects; Ischemic Stroke - complications; Ischemic Stroke - drug therapy; Neurokinin-1 Receptor Antagonists - pharmacology; Neurokinin-1 Receptor Antagonists - therapeutic use; Original; Receptors, Neurokinin-1 - metabolism; Sheep; translation; intracranial pressure; NK1-R; Cerebral edema; stroke