Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury

• Published in: Science advances Vol. 9; no. 50; p. eadj2417
• Main Authors: MacLean, Mark A., Muradov, Jamil H., Greene, Ryan, Van Hameren, Gerben, Clarke, David B., Dreier, Jens P., Okonkwo, David O., Friedman, Alon
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 15.12.2023
• Subjects: Animals; Brain - metabolism; Brain Injuries, Traumatic - drug therapy; Electrocorticography; Memantine - pharmacology; Neuroscience; Rats; Receptors, N-Methyl-D-Aspartate - metabolism; SciAdv r-articles

Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on electrically triggered CSDs in healthy and brain-injured animals. Rats received either one moderate or four daily repetitiv...