Low immunoglobulin M memory B-cell percentage in patients with heterotaxy syndrome correlates with the risk of severe bacterial infection
Background: Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its associ...
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Published in | Pediatric research Vol. 79; no. 2; pp. 271 - 277 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.02.2016
Nature Publishing Group |
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Abstract | Background:
Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its association with SBI.
Methods:
We enrolled 46 (M/F 29/17) heterotaxy syndrome patients (42 right atrial isomerism (RAI) and 4 left atrial isomerism (LAI)) aged > 1 y during the period 2010–2012 in a tertiary care center. We analyzed IgM
+
CD27
+
memory B-cell percentages. Patients with simple and complex CHD served as controls.
Results:
The mean IgM memory B-cell percentages were the lowest in the heterotaxy syndrome group, compared with those in complex and simple CHD groups (1.8 ± 2.1 vs. 3.9 ± 3.2 vs. 5.1 ± 4.7,
P
< 0.001). In the heterotaxy syndrome group, 41.3% had low IgM memory B-cell percentages (<1% of B cells). Seven had a history of community-acquired SBI and 85.7% of these had low IgM memory B-cell percentages, which was the only significant factors related to community-acquired SBI (
P
= 0.028).
Conclusion:
The memory B cell and IgM memory B-cell percentages are low in patients with heterotaxy syndrome, and the presence of IgM memory B-cell percentage < 1% correlates with community-acquired SBI. |
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AbstractList | Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its association with SBI.
We enrolled 46 (M/F 29/17) heterotaxy syndrome patients (42 right atrial isomerism (RAI) and 4 left atrial isomerism (LAI)) aged > 1 y during the period 2010-2012 in a tertiary care center. We analyzed IgM(+)CD27(+) memory B-cell percentages. Patients with simple and complex CHD served as controls.
The mean IgM memory B-cell percentages were the lowest in the heterotaxy syndrome group, compared with those in complex and simple CHD groups (1.8 ± 2.1 vs. 3.9 ± 3.2 vs. 5.1 ± 4.7, P < 0.001). In the heterotaxy syndrome group, 41.3% had low IgM memory B-cell percentages (<1% of B cells). Seven had a history of community-acquired SBI and 85.7% of these had low IgM memory B-cell percentages, which was the only significant factors related to community-acquired SBI (P = 0.028).
The memory B cell and IgM memory B-cell percentages are low in patients with heterotaxy syndrome, and the presence of IgM memory B-cell percentage < 1% correlates with community-acquired SBI. Background: Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its association with SBI. Methods: We enrolled 46 (M/F 29/17) heterotaxy syndrome patients (42 right atrial isomerism (RAI) and 4 left atrial isomerism (LAI)) aged > 1 y during the period 2010–2012 in a tertiary care center. We analyzed IgM + CD27 + memory B-cell percentages. Patients with simple and complex CHD served as controls. Results: The mean IgM memory B-cell percentages were the lowest in the heterotaxy syndrome group, compared with those in complex and simple CHD groups (1.8 ± 2.1 vs. 3.9 ± 3.2 vs. 5.1 ± 4.7, P < 0.001). In the heterotaxy syndrome group, 41.3% had low IgM memory B-cell percentages (<1% of B cells). Seven had a history of community-acquired SBI and 85.7% of these had low IgM memory B-cell percentages, which was the only significant factors related to community-acquired SBI ( P = 0.028). Conclusion: The memory B cell and IgM memory B-cell percentages are low in patients with heterotaxy syndrome, and the presence of IgM memory B-cell percentage < 1% correlates with community-acquired SBI. BACKGROUNDPatients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its association with SBI.METHODSWe enrolled 46 (M/F 29/17) heterotaxy syndrome patients (42 right atrial isomerism (RAI) and 4 left atrial isomerism (LAI)) aged > 1 y during the period 2010-2012 in a tertiary care center. We analyzed IgM(+)CD27(+) memory B-cell percentages. Patients with simple and complex CHD served as controls.RESULTSThe mean IgM memory B-cell percentages were the lowest in the heterotaxy syndrome group, compared with those in complex and simple CHD groups (1.8 ± 2.1 vs. 3.9 ± 3.2 vs. 5.1 ± 4.7, P < 0.001). In the heterotaxy syndrome group, 41.3% had low IgM memory B-cell percentages (<1% of B cells). Seven had a history of community-acquired SBI and 85.7% of these had low IgM memory B-cell percentages, which was the only significant factors related to community-acquired SBI (P = 0.028).CONCLUSIONThe memory B cell and IgM memory B-cell percentages are low in patients with heterotaxy syndrome, and the presence of IgM memory B-cell percentage < 1% correlates with community-acquired SBI. Background: Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI). We sought to define the change of a novel immunologic marker, the immunoglobulin M (IgM) memory B-cell percentage, and its association with SBI. Methods: We enrolled 46 (M/F 29/17) heterotaxy syndrome patients (42 right atrial isomerism (RAI) and 4 left atrial isomerism (LAI)) aged > 1 y during the period 2010-2012 in a tertiary care center. We analyzed IgM+CD27+ memory B-cell percentages. Patients with simple and complex CHD served as controls. Results: The mean IgM memory B-cell percentages were the lowest in the heterotaxy syndrome group, compared with those in complex and simple CHD groups (1.8 ± 2.1 vs. 3.9 ± 3.2 vs. 5.1 ± 4.7, P < 0.001). In the heterotaxy syndrome group, 41.3% had low IgM memory B-cell percentages (<1% of B cells). Seven had a history of community-acquired SBI and 85.7% of these had low IgM memory B-cell percentages, which was the only significant factors related to community-acquired SBI (P = 0.028). Conclusion: The memory B cell and IgM memory B-cell percentages are low in patients with heterotaxy syndrome, and the presence of IgM memory B-cell percentage < 1% correlates with community-acquired SBI. |
Author | Hsu, Hui-Wen Lee, Ping-Ing Huang, Li-Min Wu, Mei-Hwan Wang, Jou-Kou Chiu, Shuenn-Nan Lu, Chun-Yi Lin, Ming-Tai Shao, Pei-Lan Chang, Luan-Yin |
Author_xml | – sequence: 1 givenname: Shuenn-Nan surname: Chiu fullname: Chiu, Shuenn-Nan organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 2 givenname: Pei-Lan surname: Shao fullname: Shao, Pei-Lan organization: Department of Laboratory Medicine, National Taiwan University Hospital Hsin-Chu Branch, Department of Pediatrics, National Taiwan University Hospital Hsin-Chu Branch – sequence: 3 givenname: Jou-Kou surname: Wang fullname: Wang, Jou-Kou organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 4 givenname: Hui-Wen surname: Hsu fullname: Hsu, Hui-Wen organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 5 givenname: Ming-Tai surname: Lin fullname: Lin, Ming-Tai organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 6 givenname: Luan-Yin surname: Chang fullname: Chang, Luan-Yin organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 7 givenname: Chun-Yi orcidid: 0000-0002-5240-2808 surname: Lu fullname: Lu, Chun-Yi organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 8 givenname: Ping-Ing surname: Lee fullname: Lee, Ping-Ing organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 9 givenname: Li-Min surname: Huang fullname: Huang, Li-Min organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University – sequence: 10 givenname: Mei-Hwan surname: Wu fullname: Wu, Mei-Hwan email: wumh@ntu.edu.tw organization: Department of Pediatrics, National Taiwan University Hospital and Medical College, National Taiwan University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26524717$$D View this record in MEDLINE/PubMed |
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Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial... Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial infection (SBI).... Background: Patients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial... BACKGROUNDPatients with heterotaxy syndrome, commonly associated with complex congenital heart disease (CHD), exhibit a higher risk of severe bacterial... |
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SubjectTerms | 692/499 692/53/2423 Adolescent B-Lymphocytes - immunology Bacterial infections Bacterial Infections - diagnosis Bacterial Infections - immunology Bacterial Infections - microbiology Cardiology Case-Control Studies Child Child, Preschool Congenital diseases Female Flow Cytometry Heterotaxy Syndrome - complications Heterotaxy Syndrome - diagnosis Heterotaxy Syndrome - immunology Humans Immunocompromised Host Immunoglobulin M - immunology Immunoglobulins Immunologic Memory Immunophenotyping - methods Infant Lymphocyte Count Male Medicine Medicine & Public Health Opportunistic Infections - diagnosis Opportunistic Infections - immunology Opportunistic Infections - microbiology Pediatric Surgery Pediatrics Phenotype Risk Assessment Risk Factors Severity of Illness Index Tertiary Care Centers translational-investigation |
Title | Low immunoglobulin M memory B-cell percentage in patients with heterotaxy syndrome correlates with the risk of severe bacterial infection |
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