Effects of Surgical Levels of Propofol and Sevoflurane Anesthesia on Cerebral Blood Flow in Healthy Subjects Studied with Positron Emission Tomography

• Published in: Anesthesiology (Philadelphia) Vol. 96; no. 6; pp. 1358 - 1370
• Main Authors: Kaisti, Kaike K., Metsähonkala, Liisa, Teräs, Mika, Oikonen, Vesa, Aalto, Sargo, Jääskeläinen, Satu, Hinkka, Susanna, Scheinin, Harry
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.06.2002
• Subjects: Adult; Anesthetics, Inhalation - pharmacology; Anesthetics, Intravenous - pharmacology; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Blood Pressure - drug effects; Cerebrovascular Circulation - drug effects; Dose-Response Relationship, Drug; Electroencephalography - drug effects; Humans; Male; Medical sciences; Methyl Ethers - pharmacology; Neuropharmacology; Pharmacology. Drug treatments; Propofol - pharmacology; Sevoflurane; Tomography, Emission-Computed; Volatile compound; Human; Regional blood flow; Intravenous administration; Healthy subject; Central nervous system; Nervous system; General anesthesia; Inhalation; Sevoflurane; General anesthetic; Activity concentration relation; Hemodynamics; Propofol; Positron emission tomography; Brain (vertebrata); Halogen Organic compounds

The authors report a positron emission tomography (PET) study on humans with parallel exploration of the dose-dependent effects of an intravenous (propofol) and a volatile (sevoflurane) anesthetic agent on regional cerebral blood flow (rCBF) using quantitative and relative (Statistical Parametric Ma...