Decreased glucose effectiveness but not insulin resistance in glucose-tolerant offspring of Japanese non—insulin-dependent diabetic patients: A minimal-model analysis

• Published in: Metabolism, clinical and experimental Vol. 46; no. 8; pp. 880 - 883
• Main Authors: Doi, Kentaro, Taniguchi, Ataru, Nakai, Yoshikatsu, Kawamura, Hitomi, Higaki, Yasuki, Yokoi, Hideki, Tanaka, Hiroaki, Fujitani, Junzo, Suzuki, Masashige, Tokuyama, Kumpei, Sakai, Masahiko, Fukushima, Mitsuo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.1997; Elsevier
• Subjects: Biological and medical sciences; Blood Glucose - metabolism; Case-Control Studies; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Japan; Male; Medical sciences; Time Factors; Japan; Endocrinopathy; Human; Pancreatic hormone; Genetic inheritance; Pathogenesis; Glucose; Metabolism; Non insulin dependent diabetes; Insulin; Japanese; Endocrine secretion; Protein hormone; Target tissue resistance; Sensitivity

The aim of the study was to estimate insulin sensitivity (SI), insulin secretion, and glucose effectiveness (SG) in 10 subjects with normal glucose tolerance (eight men and two women) with a family history of non—insulin-dependent diabetes mellitus (NIDDM offspring). Ten glucose-tolerant subjects (e...