Inhibition of cytokine production by the traditional oriental medicine, ‘Gamcho-Sasim-Tang’ in mitogen-stimulated peripheral blood mononuclear cells from Adamantiades-Behçet's patients

Gamcho-Sasim-Tang (GS-Tang) is a traditional Chinese medication, which has been successfully used in Korea for the treatment of Adamantiades-Behçet's disease (ABD). We investigated the modulation effects of GS-Tang on cytokine production from phytohaemagglutinin-stimulated peripheral blood mono...

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Published inJournal of ethnopharmacology Vol. 83; no. 1; pp. 123 - 128
Main Authors Kim, Mi-Sun, Chung, Hwan-Suck, Lee, Jun-Gyoung, Lim, Woon Ki, Hwang, Chung-Yeon, Lee, Eon-Jeong, Cho, Kwang-Ho, Wi, Dac-Han, Kim, Hyung-Min
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.11.2002
Elsevier
Subjects
Adamantiades-Behçet's disease
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Adjuvants, Immunologic - therapeutic use
Adult
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Behcet Syndrome - drug therapy
Biological and medical sciences
Cytokines - drug effects
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Female
Gamcho-Sasim-Tang
General pharmacology
Humans
IFN-γ
IL-1β
Interferon-gamma - drug effects
Interleukin-1 - metabolism
Leukocytes, Mononuclear - drug effects
Male
Medical sciences
Middle Aged
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
TNF-α
Tumor Necrosis Factor-alpha - drug effects
Asia
China
IFN-γ
Adamantiades-Behçet's disease
TNF-α
Gamcho-Sasim-Tang
IL-1β
Human
Biological fluid
Drug combination
Pharmacognosy
Oriental medicine
Antiinflammatory agent
Cytokine
Interleukin 1β
Inflammation
In vitro
Biological activity
Blood
Medicinal plant
Immunomodulator
Mononuclear cell
Folk medicine
T-Lymphocyte
Plant origin
Mechanism of action
Tumor necrosis factor α
Gamma interferon
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Abstract Gamcho-Sasim-Tang (GS-Tang) is a traditional Chinese medication, which has been successfully used in Korea for the treatment of Adamantiades-Behçet's disease (ABD). We investigated the modulation effects of GS-Tang on cytokine production from phytohaemagglutinin-stimulated peripheral blood mononuclear cells of Behçet's patients. ABD is a systemic inflammatory disorder and might involve immune dysfunction. Cytokines involved in the regulation of inflammatory reactions and immune responses may play a role in the pathogenesis of ABD. GS-Tang (1 mg/ml) significantly inhibited the production of proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), compared to absence of GS-Tang (by 42.0±6.6% inhibition for TNF-α and 95.9±5.7% for IL-1β, P<0.05). GS-Tang also inhibited the production of IFN-γ, immunoregulatory T helper cell type 1 cytokine, by 80.2±5.3% ( P=0.001). The inhibitory effects of GS-Tang on cytokine production showed dose-dependent manner. Our results suggest that GS-Tang might have anti-inflammatory and immuno-regulatory effects through the cytokine modulation.
AbstractList Gamcho-Sasim-Tang (GS-Tang) is a traditional Chinese medication, which has been successfully used in Korea for the treatment of Adamantiades-Behçet's disease (ABD). We investigated the modulation effects of GS-Tang on cytokine production from phytohaemagglutinin-stimulated peripheral blood mononuclear cells of Behçet's patients. ABD is a systemic inflammatory disorder and might involve immune dysfunction. Cytokines involved in the regulation of inflammatory reactions and immune responses may play a role in the pathogenesis of ABD. GS-Tang (1 mg/ml) significantly inhibited the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), compared to absence of GS-Tang (by 42.0+/-6.6% inhibition for TNF-alpha and 95.9+/-5.7% for IL-1 beta, P<0.05). GS-Tang also inhibited the production of IFN-gamma, immunoregulatory T helper cell type 1 cytokine, by 80.2+/-5.3% (P=0.001). The inhibitory effects of GS-Tang on cytokine production showed dose-dependent manner. Our results suggest that GS-Tang might have anti-inflammatory and immuno-regulatory effects through the cytokine modulation.
Gamcho-Sasim-Tang (GS-Tang) is a traditional Chinese medication, which has been successfully used in Korea for the treatment of Adamantiades-Behçet's disease (ABD). We investigated the modulation effects of GS-Tang on cytokine production from phytohaemagglutinin-stimulated peripheral blood mononuclear cells of Behçet's patients. ABD is a systemic inflammatory disorder and might involve immune dysfunction. Cytokines involved in the regulation of inflammatory reactions and immune responses may play a role in the pathogenesis of ABD. GS-Tang (1 mg/ml) significantly inhibited the production of proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), compared to absence of GS-Tang (by 42.0±6.6% inhibition for TNF-α and 95.9±5.7% for IL-1β, P<0.05). GS-Tang also inhibited the production of IFN-γ, immunoregulatory T helper cell type 1 cytokine, by 80.2±5.3% ( P=0.001). The inhibitory effects of GS-Tang on cytokine production showed dose-dependent manner. Our results suggest that GS-Tang might have anti-inflammatory and immuno-regulatory effects through the cytokine modulation.
Author Chung, Hwan-Suck
Hwang, Chung-Yeon
Cho, Kwang-Ho
Kim, Hyung-Min
Lim, Woon Ki
Kim, Mi-Sun
Lee, Eon-Jeong
Lee, Jun-Gyoung
Wi, Dac-Han
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CitedBy_id crossref_primary_10_1186_1476_9255_8_35
crossref_primary_10_1097_MD_0000000000010165
crossref_primary_10_1111_j_1740_0929_2011_00942_x
crossref_primary_10_3390_nu13010046
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Issue 1
Keywords IFN-γ
Adamantiades-Behçet's disease
TNF-α
Gamcho-Sasim-Tang
IL-1β
Human
Biological fluid
Drug combination
Pharmacognosy
Oriental medicine
Antiinflammatory agent
Cytokine
Interleukin 1β
Inflammation
In vitro
Biological activity
Blood
Medicinal plant
Immunomodulator
Mononuclear cell
Folk medicine
T-Lymphocyte
Plant origin
Mechanism of action
Tumor necrosis factor α
Gamma interferon
Language English
License CC BY 4.0
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Elsevier
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Snippet Gamcho-Sasim-Tang (GS-Tang) is a traditional Chinese medication, which has been successfully used in Korea for the treatment of Adamantiades-Behçet's disease...
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SubjectTerms Adamantiades-Behçet's disease
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Adjuvants, Immunologic - therapeutic use
Adult
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Behcet Syndrome - drug therapy
Biological and medical sciences
Cytokines - drug effects
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Female
Gamcho-Sasim-Tang
General pharmacology
Humans
IFN-γ
IL-1β
Interferon-gamma - drug effects
Interleukin-1 - metabolism
Leukocytes, Mononuclear - drug effects
Male
Medical sciences
Middle Aged
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
TNF-α
Tumor Necrosis Factor-alpha - drug effects
Title Inhibition of cytokine production by the traditional oriental medicine, ‘Gamcho-Sasim-Tang’ in mitogen-stimulated peripheral blood mononuclear cells from Adamantiades-Behçet's patients
URI https://dx.doi.org/10.1016/S0378-8741(02)00221-0
https://www.ncbi.nlm.nih.gov/pubmed/12413717
https://search.proquest.com/docview/72665101
Volume 83
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