ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats

• Published in: American journal of respiratory cell and molecular biology Vol. 44; no. 2; pp. 185 - 196
• Main Authors: Farraj, Aimen K, Hazari, Mehdi S, Haykal-Coates, Najwa, Lamb, Christina, Winsett, Darrell W, Ge, Yue, Ledbetter, Allen D, Carll, Alex P, Bruno, Maribel, Ghio, Andy, Costa, Daniel L
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.02.2011
• Subjects: Airway Resistance - drug effects; Animals; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - genetics; Arrhythmias, Cardiac - physiopathology; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - cytology; Carbon - administration & dosage; Carbon - toxicity; Cardiovascular System - drug effects; Cardiovascular System - physiopathology; Coal Ash; Connexin 43 - metabolism; Electrocardiography; Heart Rate - drug effects; Heart Ventricles - drug effects; Heart Ventricles - metabolism; Inflammation Mediators - blood; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Particulate Matter - administration & dosage; Particulate Matter - toxicity; Potassium Channels, Inwardly Rectifying - metabolism; Rats; Rats, Inbred SHR; Telemetry; Transition Elements - administration & dosage; Transition Elements - toxicity; Vagus Nerve - drug effects; Vagus Nerve - physiopathology

Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals Fe, Ni, and V, and when released as a fugitive pa...