The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary

• Published in: Gene Expression Patterns Vol. 6; no. 8; pp. 900 - 907
• Main Authors: McGurk, Leeanne, Tzolovsky, George, Spears, Norah, Bownes, Mary
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2006
• Subjects: Animals; Class V and VI unconventional myosin; Drosophila; Female; Gene Expression Regulation, Developmental; Genomic organisation; Granulosa Cells - metabolism; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mouse ovarian follicle development; Myosin Heavy Chains - metabolism; Myosin Type V - metabolism; Ovarian Follicle - growth & development; Ovarian Follicle - metabolism; Ovary - cytology; Ovary - growth & development; Ovary - metabolism; RNA localisation; RNA, Messenger - metabolism; Immunohistochemistry; Mouse ovarian follicle development; Genomic organisation; Class V and VI unconventional myosin; RNA localisation
• ISSN: 1567-133X; 1872-7298
• DOI: 10.1016/j.modgep.2006.03.002

There are 16 classes of unconventional myosins. Class V myosins have been shown to be involved in transporting cargo to and from the cell periphery. Class VI myosins have also been shown to transport cargo from the cell periphery, although it seems that these proteins have many roles which include the mediation of cell migration and stereocillia stabilisation. With the requirement of myosin VI for Drosophila oogenesis, the localised expression of Myosin V in the developing egg chamber and recent mounting evidence which links myosin VI to the migration of human ovarian cancer cell lines, we wanted to investigate the expression pattern of these two myosin classes in the normal mouse ovary. Here we show that these myosins are expressed, localised and regulated within the oocyte and granulosa cells of the developing mouse follicle.