The inebri-actometer: a device for measuring the locomotor activity of Drosophila exposed to ethanol vapor
Drosophila melanogaster can be used as a model organism for probing the genetic basis for alcohol sensitivity. In this paper, we describe a new device, the inebri-actometer, which measures the locomotor activity of up to 128 individual flies simultaneously. The device consists of 128 pairs of emitte...
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Published in | Journal of neuroscience methods Vol. 107; no. 1; pp. 93 - 99 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Amsterdam
Elsevier B.V
30.05.2001
Elsevier Science |
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Abstract | Drosophila melanogaster can be used as a model organism for probing the genetic basis for alcohol sensitivity. In this paper, we describe a new device, the inebri-actometer, which measures the locomotor activity of up to 128 individual flies simultaneously. The device consists of 128 pairs of emitter/detector photodiodes connected in series through a computer interlink. A single fly is placed in each of the 128 chambers and humidified air or air containing variable amounts of ethanol vapor is pumped through the chambers. When a fly blocks the infrared signal transmitted by an emitter photodiode, the computer records one movement for that fly. We present preliminary results showing the effect of ethanol on the activity of wild-type Oregon R
Drosophila. Five preliminary runs with 95% ethanol vapor revealed that this concentration induces an approximately 3- to 4-fold increase in locomotor activity which peaks at about 5 min after the addition of ethanol vapor. This is followed by a gradual decrease in activity leading to a nearly total cessation of movement after 30 min. Statistically significant dose-related activity increases were obtained for ethanol concentrations of 8, 19, 50, and 100% of maximum, assessed in two replications at each dose. Unlike the complete suppression of locomotion seen in the last 10 min of the session at maximum ethanol exposure, the initial stimulation effect at the 19% concentration was maintained across the 30-min session. |
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AbstractList | Drosophila melanogaster can be used as a model organism for probing the genetic basis for alcohol sensitivity. In this paper, we describe a new device, the inebri-actometer, which measures the locomotor activity of up to 128 individual flies simultaneously. The device consists of 128 pairs of emitter/detector photodiodes connected in series through a computer interlink. A single fly is placed in each of the 128 chambers and humidified air or air containing variable amounts of ethanol vapor is pumped through the chambers. When a fly blocks the infrared signal transmitted by an emitter photodiode, the computer records one movement for that fly. We present preliminary results showing the effect of ethanol on the activity of wild-type Oregon R Drosophila. Five preliminary runs with 95% ethanol vapor revealed that this concentration induces an approximately 3- to 4-fold increase in locomotor activity which peaks at about 5 min after the addition of ethanol vapor. This is followed by a gradual decrease in activity leading to a nearly total cessation of movement after 30 min. Statistically significant dose-related activity increases were obtained for ethanol concentrations of 8, 19, 50, and 100% of maximum, assessed in two replications at each dose. Unlike the complete suppression of locomotion seen in the last 10 min of the session at maximum ethanol exposure, the initial stimulation effect at the 19% concentration was maintained across the 30-min session. Drosophila melanogaster can be used as a model organism for probing the genetic basis for alcohol sensitivity. In this paper, we describe a new device, the inebri-actometer, which measures the locomotor activity of up to 128 individual flies simultaneously. The device consists of 128 pairs of emitter/detector photodiodes connected in series through a computer interlink. A single fly is placed in each of the 128 chambers and humidified air or air containing variable amounts of ethanol vapor is pumped through the chambers. When a fly blocks the infrared signal transmitted by an emitter photodiode, the computer records one movement for that fly. We present preliminary results showing the effect of ethanol on the activity of wild-type Oregon R Drosophila. Five preliminary runs with 95% ethanol vapor revealed that this concentration induces an approximately 3- to 4-fold increase in locomotor activity which peaks at about 5 min after the addition of ethanol vapor. This is followed by a gradual decrease in activity leading to a nearly total cessation of movement after 30 min. Statistically significant dose-related activity increases were obtained for ethanol concentrations of 8, 19, 50, and 100% of maximum, assessed in two replications at each dose. Unlike the complete suppression of locomotion seen in the last 10 min of the session at maximum ethanol exposure, the initial stimulation effect at the 19% concentration was maintained across the 30-min session. |
Author | Wang, X Fowler, S.C Large, A Ratzlaff, K.L Ruden, D.M Parr, J |
Author_xml | – sequence: 1 givenname: J surname: Parr fullname: Parr, J organization: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA – sequence: 2 givenname: A surname: Large fullname: Large, A organization: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA – sequence: 3 givenname: X surname: Wang fullname: Wang, X organization: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA – sequence: 4 givenname: S.C surname: Fowler fullname: Fowler, S.C organization: Department of Pharmacology and Toxicology and Department of Human Development, University of Kansas, Lawrence, KS 66045, USA – sequence: 5 givenname: K.L surname: Ratzlaff fullname: Ratzlaff, K.L organization: Instrumentation Design Laboratory, University of Kansas, Lawrence, KS 66045, USA – sequence: 6 givenname: D.M surname: Ruden fullname: Ruden, D.M email: douglasr@uab.edu organization: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA |
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Cites_doi | 10.1016/S0896-6273(00)00101-X 10.1038/ng0996-98 10.1007/978-1-4613-2719-6_3 10.1126/science.2882604 10.1073/pnas.79.24.7900 10.1111/j.1530-0277.1996.tb01705.x 10.1126/science.8209252 10.1176/ajp.151.2.184 10.1111/j.1530-0277.2000.tb02075.x 10.1242/dev.125.6.1049 10.1016/S0960-9822(00)00336-5 10.1126/science.6474187 10.1126/science.278.5338.698 10.1111/j.1530-0277.1995.tb01606.x 10.1093/genetics/114.1.145 10.1016/S0092-8674(00)81205-2 10.1016/S0092-8674(00)80365-7 |
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Keywords | Behavior Actometer Ethanol sensitivity Drosophila Locomotor activity Animal model Methodology Ethanol Insecta Experimental device Genetic determinism Drosophilidae Dose activity relation Locomotion Animal activity Spontaneous physical activity Arthropoda Animal Measurement method Invertebrata Drosophila melanogaster Diptera |
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SubjectTerms | Actometer Alcoholism - genetics Alcoholism - physiopathology Animals Behavior Biological and medical sciences Data Interpretation, Statistical Dose-Response Relationship, Drug Drosophila Drosophila - drug effects Drosophila - physiology Ethanol - pharmacology Ethanol sensitivity Fundamental and applied biological sciences. Psychology Locomotor activity Methodology. Experimentation Motor Activity - drug effects Motor Activity - physiology Neuropharmacology - instrumentation Neuropharmacology - methods Neurophysiology - instrumentation Neurophysiology - methods Photic Stimulation - instrumentation Photic Stimulation - methods Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychometrics. Statistics. Methodology Signal Processing, Computer-Assisted - instrumentation |
Title | The inebri-actometer: a device for measuring the locomotor activity of Drosophila exposed to ethanol vapor |
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