Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms

• Published in: International journal of pharmaceutics Vol. 277; no. 1; pp. 141 - 153
• Main Authors: Hoffman, Amnon, Stepensky, David, Lavy, Eran, Eyal, Sara, Klausner, Eytan, Friedman, Michael
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 11.06.2004; Elsevier
• Subjects: Animals; Bioavailability; Biological and medical sciences; Controlled release; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - pharmacokinetics; Delayed-Action Preparations - pharmacology; Gastrointestinal Tract - drug effects; Gastrointestinal Tract - metabolism; Gastroretentive dosage forms; General pharmacology; Humans; Levodopa; Medical sciences; Metformin; Pharmaceutical technology. Pharmaceutical industry; Pharmacodynamics; Pharmacokinetics; Pharmacology. Drug treatments; Riboflavin; Pharmacodynamics; Riboflavin; Bioavailability; Metformin; Levodopa; Pharmacokinetics; Controlled release; Gastroretentive dosage forms; Delivery system; Stomach; Pharmaceutical technology; Residence time; Controlled release form; Vitamin; Oral administration; Hypoglycemic agent; Biguanides; Levedepe Riboflavin; Controlled release: Bioavailability

Controlled release gastroretentive dosage forms (CR-GRDF) enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improve the bioavailability of medications that are characterized by a narrow absorption window. CR-GRDF provide a means to utilize al...