Octreotide improves burn-induced intestinal injury in the rat
The local thermal trauma activates a number of systemic mediator cascades, e.g. a complement activation, cytokine production, resulting in a generalized sequestration and a priming of local and systemic neutrophils and macrophages. We aimed to determine the possible protective effect of octreotide (...
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Published in | Peptides (New York, N.Y. : 1980) Vol. 24; no. 1; pp. 123 - 127 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
2003
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Abstract | The local thermal trauma activates a number of systemic mediator cascades, e.g. a complement activation, cytokine production, resulting in a generalized sequestration and a priming of local and systemic neutrophils and macrophages. We aimed to determine the possible protective effect of octreotide (OCT), a synthetic somatostatin analogue, against burn-induced intestinal tissue damage possibly by inhibiting neutrophil infiltration.
Under brief ether anaesthesia, shaved dorsum of the rats was exposed to 90
°C bath for 10
s to induce burn injury. Rats were decapitated either 3, 24 or 72
h after burn injury. Octreotide (10
μg/kg) or saline was administered subcutaneously (s.c.) immediately after the burn injury. In the 24- and 72-h burn groups, OCT injections were repeated three times daily. In the sham group the same protocol was applied except that the dorsum was dipped in a 25
°C water bath for 10
s Malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) activity were determined in the intestinal tissue. The results demonstrate that burn injury results in significant neutrophil accumulation, as evidenced by increases in MPO activity. The increase in MDA and the concomitant decrease in GSH levels demonstrate the role of oxidative mechanisms in burn injury. OCT may have some beneficial therapeutic effects by reducing neutrophil-dependent injury and related lipid peroxidation following burn trauma. |
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AbstractList | The local thermal trauma activates a number of systemic mediator cascades, e.g. a complement activation, cytokine production, resulting in a generalized sequestration and a priming of local and systemic neutrophils and macrophages. We aimed to determine the possible protective effect of octreotide (OCT), a synthetic somatostatin analogue, against burn-induced intestinal tissue damage possibly by inhibiting neutrophil infiltration.
Under brief ether anaesthesia, shaved dorsum of the rats was exposed to 90
°C bath for 10
s to induce burn injury. Rats were decapitated either 3, 24 or 72
h after burn injury. Octreotide (10
μg/kg) or saline was administered subcutaneously (s.c.) immediately after the burn injury. In the 24- and 72-h burn groups, OCT injections were repeated three times daily. In the sham group the same protocol was applied except that the dorsum was dipped in a 25
°C water bath for 10
s Malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) activity were determined in the intestinal tissue. The results demonstrate that burn injury results in significant neutrophil accumulation, as evidenced by increases in MPO activity. The increase in MDA and the concomitant decrease in GSH levels demonstrate the role of oxidative mechanisms in burn injury. OCT may have some beneficial therapeutic effects by reducing neutrophil-dependent injury and related lipid peroxidation following burn trauma. The local thermal trauma activates a number of systemic mediator cascades, e.g. a complement activation, cytokine production, resulting in a generalized sequestration and a priming of local and systemic neutrophils and macrophages. We aimed to determine the possible protective effect of octreotide (OCT), a synthetic somatostatin analogue, against burn-induced intestinal tissue damage possibly by inhibiting neutrophil infiltration. Under brief ether anaesthesia, shaved dorsum of the rats was exposed to 90 degrees C bath for 10s to induce burn injury. Rats were decapitated either 3, 24 or 72 h after burn injury. Octreotide (10 microg/kg) or saline was administered subcutaneously (s.c.) immediately after the burn injury. In the 24- and 72-h burn groups, OCT injections were repeated three times daily. In the sham group the same protocol was applied except that the dorsum was dipped in a 25 degrees C water bath for 10 s Malondialdehyde (MDA) and glutathione (GSH) levels and myeloperoxidase (MPO) activity were determined in the intestinal tissue. The results demonstrate that burn injury results in significant neutrophil accumulation, as evidenced by increases in MPO activity. The increase in MDA and the concomitant decrease in GSH levels demonstrate the role of oxidative mechanisms in burn injury. OCT may have some beneficial therapeutic effects by reducing neutrophil-dependent injury and related lipid peroxidation following burn trauma. |
Author | Şehirli, A.Özer Şatiroǧlu, Handan Kaçmaz, Ayhan Yeǧen, Berrak Ç. Şener, Göksel Ayanoǧlu-Dülger, Gül |
Author_xml | – sequence: 1 givenname: Göksel surname: SENER fullname: SENER, Göksel organization: Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey – sequence: 2 givenname: A. Özer surname: SEHIRLI fullname: SEHIRLI, A. Özer organization: Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey – sequence: 3 givenname: Handan surname: SATIROGLU fullname: SATIROGLU, Handan organization: Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey – sequence: 4 givenname: Ayhan surname: KACMAZ fullname: KACMAZ, Ayhan organization: Department of Surgery, Haydarpaş a Numune Hospital, Istanbul, Turkey – sequence: 5 givenname: Gül surname: AYANOGLU-DÜLGER fullname: AYANOGLU-DÜLGER, Gül organization: Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey – sequence: 6 givenname: Berrak C surname: YEGEN fullname: YEGEN, Berrak C organization: Department of Physiology, School of Medicine, Istanbul, Turkey |
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Keywords | Burn Lipid peroxidation Octreotide Myeloperoxidase Glutathione |
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SubjectTerms | Animals Biological and medical sciences Burn Burns - drug therapy Burns - metabolism Female Fundamental and applied biological sciences. Psychology Glutathione Glutathione - metabolism Intestinal Mucosa - metabolism Intestines - enzymology Intestines - injuries Lipid peroxidation Male Malondialdehyde - metabolism Myeloperoxidase Octreotide Octreotide - therapeutic use Peroxidase - metabolism Rats Rats, Wistar |
Title | Octreotide improves burn-induced intestinal injury in the rat |
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