Rapid drug desensitization in seven patients with delayed hypersensitivity reactions to biologics and targeted therapies: Reason, successes, and failures

• Published in: Allergy and asthma proceedings Vol. 46; no. 2; p. e70
• Main Authors: Onalan, Tugba, Colkesen, Fatih, Gerek, Mehmet Emin, Akkus, Fatma Arzu, Evcen, Recep, Arslan, Sevket
• Format: Journal Article
• Language: English
• Published: United States 01.03.2025
• Subjects: Adult; Aged; Biological Products - adverse effects; Desensitization, Immunologic - methods; Drug Hypersensitivity - diagnosis; Drug Hypersensitivity - etiology; Drug Hypersensitivity - immunology; Drug Hypersensitivity - therapy; Female; Humans; Hypersensitivity, Delayed - diagnosis; Hypersensitivity, Delayed - immunology; Hypersensitivity, Delayed - therapy; Male; Middle Aged; Molecular Targeted Therapy - adverse effects; Treatment Outcome

Rapid drug desensitization (RDD) is commonly used for immediate drug hypersensitivity reactions (DHR) across various drugs. In delayed DHRs, the conventional approach is slow desensitization; however, limitations may arise due to drug-specific or disease-related factors. With the increasing role of...