Update of Alpha Fetoprotein Growth-Inhibitory Peptides as Biotherapeutic Agents for Tumor Growth and Metastasis

• Published in: Chemotherapy (Basel) Vol. 52; no. 2; pp. 83 - 90
• Main Authors: Mizejewski, G.J., Muehlemann, M., Dauphinee, M.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.01.2006; S. Karger AG
• Subjects: alpha-Fetoproteins - chemistry; alpha-Fetoproteins - pharmacology; Amino acids; Animals; Antineoplastic agents; Antineoplastic Agents - pharmacology; Ascites - drug therapy; Ascites - pathology; Biological and medical sciences; Cell Line, Tumor; Cell Proliferation - drug effects; Chemotherapy; Drug Screening Assays, Antitumor; Experimental Chemotherapy; Humans; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - pathology; Medical sciences; Mice; Mice, Nude; Neoplasm Metastasis; Oncology; Peptide Fragments - chemistry; Peptide Fragments - pharmacology; Peptides; Pharmacology. Drug treatments; Proteins; Quantitative Structure-Activity Relationship; Transplantation, Heterologous; Tumors; Alpha fetoprotein; Tumor growth; Peptides; Cytostasis; G-coupled receptors; Tumor metastasis; Antineoplastic agent; Growth inhibitor; Antimetastatic agent; Malignant tumor; α-Fetoprotein; Biological receptor

The present update describes the biological activities of an alpha fetoprotein (AFP)-derived peptide termed the growth-inhibitory peptide (GIP), which is a synthetic 34-amino acid segment produced from the native molecule. The GIP has been shown to be growth-suppressive in both fetal and tumor cells...