Development and Characterization of Transdermal Patches Using Novel Thymoquinone-L-Arginine-Based Polyamide Nanocapsules for Potential Use in the Management of Psoriasis

• Published in: AAPS PharmSciTech Vol. 25; no. 4; p. 69
• Main Authors: Dahmash, Eman Zmaily, Attiany, Lama Murad, Ali, Dalia, Assaf, Shereen M., Alkrad, Jamal, Alyami, Hamad
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 27.03.2024
• Subjects: Benzoquinones; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Humans; Nanocapsules - chemistry; Nylons; Pharmacology/Toxicology; Pharmacy; Psoriasis - drug therapy; Research Article; Transdermal Patch; thymoquinone; nanocapsules; transdermal patch; polyamide; arginine; psoriasis; L-arginine

Thymoquinone (TQ) is a phytochemical compound present in Nigella sativa and has potential benefits for treating dermatological conditions such as psoriasis. However, its clinical use is limited due to its restricted bioavailability, caused mainly by its low solubility and permeability. To overcome t...