Neonatal sex hormones have `organizational' effects on the hypothalamic-pituitary-adrenal axis of male rats

• Published in: Brain research. Developmental brain research Vol. 105; no. 2; pp. 295 - 307
• Main Authors: McCormick, Cheryl M, Furey, Brinley F, Child, Meredith, Sawyer, Meghan J, Donohue, Sean M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.02.1998
• Subjects: Androgen; Animals; Animals, Newborn - physiology; Corticosteroid binding globulin; Corticosterone; Corticosterone - blood; Estrogen; Estrogens - pharmacology; Glucocorticoid receptor; Gonadal Steroid Hormones - pharmacology; Gonadal Steroid Hormones - physiology; Hypothalamo-Hypophyseal System - growth & development; Hypothalamo-Hypophyseal System - physiology; Male; Mineralocorticoid receptor; Orchiectomy; Pituitary-Adrenal System - growth & development; Pituitary-Adrenal System - physiology; Rats; Receptors, Steroid - metabolism; Sex Differentiation; Sexual differentiation; Stress; Stress, Psychological - metabolism; Testosterone - pharmacology; Transcortin - metabolism; Androgen; Corticosterone; Mineralocorticoid receptor; Glucocorticoid receptor; Estrogen; Corticosteroid binding globulin; Sexual differentiation; Stress

Sex hormones have activational effects on the hypothalamic-pituitary-adrenal (HPA) axis in adulthood: For example, corticosterone release is influenced by gonadal status. These experiments investigated whether sex hormones have organizational effects on the HPA axis of male rats: Do sex hormones hav...