A Novel Temozolomide-Myricetin Drug-Drug Cocrystal: Preparation, Characterization, Property Evaluations

• Published in: Pharmaceutics Vol. 17; no. 7; p. 906
• Main Authors: Qin, Hai-Xin, Wang, Jie, Peng, Jia-Hui, Dai, Xia-Lin, Li, Cai-Wen, Lu, Tong-Bu, Chen, Jia-Mei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.07.2025; MDPI
• Subjects: Crystal structure; Crystals; Data collection; Diffraction; Drug therapy; drug-drug cocrystal; Drugs; Flavonoids; Fourier transforms; Glioma; Gliomas; Health aspects; Humidity; Hydrogen; Hydrogen bonding; Infrared spectroscopy; myricetin; Pharmaceuticals; Physicochemical properties; Radiation; Software; Spectrum analysis; stability; Structure; tabletability; Temozolomide; X-rays; China; Germany; Tianjin China; Shanghai China; temozolomide; myricetin; tabletability; drug-drug cocrystal; dissolution; crystal structure; stability

Objectives: Drug-drug cocrystals with improved properties can be used to facilitate the development of synergistic therapeutic combinations. The goal of the present study is to obtain novel drug-drug cocrystals involving two anti-glioma agents, temozolomide (TMZ) and myricetin (MYR). Methods: The no...