α-Selective glycosylation with 5-thioglucopyranosyl donors; synthesis of an IsoMaltotetraoside mimic composed of 5-thioglucopyranose units

A general method for α-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed. This methodology was utilized in the synthesis of an isomaltotetraoside analogue. A general method for α-selective glycosylation with 5-thiogluc...

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Published inBioorganic & medicinal chemistry letters Vol. 13; no. 6; pp. 1063 - 1066
Main Authors Matsuda, Hiroko, Ohara, Keiichiro, Morii, Yasuharu, Hashimoto, Masaru, Miyairi, Kazuo, Okuno, Toshikatsu
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 24.03.2003
Elsevier
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Abstract A general method for α-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed. This methodology was utilized in the synthesis of an isomaltotetraoside analogue. A general method for α-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed. A isomaltotetraoside analogue was synthesized as the application.
AbstractList A general method for alpha-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed. This methodology was utilized in the synthesis of an isomaltotetraoside analogue.
A general method for α-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed. This methodology was utilized in the synthesis of an isomaltotetraoside analogue. A general method for α-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed. A isomaltotetraoside analogue was synthesized as the application.
Author Hashimoto, Masaru
Matsuda, Hiroko
Ohara, Keiichiro
Miyairi, Kazuo
Okuno, Toshikatsu
Morii, Yasuharu
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  givenname: Hiroko
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  fullname: Matsuda, Hiroko
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  givenname: Keiichiro
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  fullname: Ohara, Keiichiro
  organization: Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-Cho 3, Hirosaki 036-8561, Japan
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  givenname: Yasuharu
  surname: Morii
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  givenname: Masaru
  surname: Hashimoto
  fullname: Hashimoto, Masaru
  email: hmasaru@cc.hirosaki-u.ac.jp
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  givenname: Toshikatsu
  surname: Okuno
  fullname: Okuno, Toshikatsu
  organization: Faculty of Agriculture and Life Science, Hirosaki University, Bunkyo-Cho 3, Hirosaki 036-8561, Japan
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Cites_doi 10.1139/v93-239
10.2174/0929867306666220207213740
10.1016/S0040-4039(00)74054-8
10.1002/anie.198602121
10.1021/jo011142u
10.1021/bi025541a
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10.1016/S0957-4166(00)80386-9
10.1016/S0040-4039(02)01760-4
10.1021/jo9800356
10.1016/S0040-4039(00)86974-9
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Issue 6
Keywords Sulfur heterocycle
Deprotection
Thioglycoside
Glycoside
Glycosylation
Selectivity
Chemical synthesis
Tetrasaccharide
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Snippet A general method for α-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed....
A general method for alpha-selective glycosylation with 5-thioglucopyranosyl donors followed by efficient deprotection of the resulting products was developed....
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SubjectTerms Carbohydrate Sequence
Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Glucose - analogs & derivatives
Glucose - chemistry
Glycosylation
Indicators and Reagents
Models, Molecular
Molecular Mimicry
Molecular Sequence Data
Monosaccharides - chemistry
Oligosaccharides - chemistry
Organic chemistry
Preparations and properties
Title α-Selective glycosylation with 5-thioglucopyranosyl donors; synthesis of an IsoMaltotetraoside mimic composed of 5-thioglucopyranose units
URI https://dx.doi.org/10.1016/S0960-894X(03)00072-6
https://www.ncbi.nlm.nih.gov/pubmed/12643912
https://search.proquest.com/docview/73116842
Volume 13
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