Response Surface Modeling of Remifentanil–Propofol Interaction on Cardiorespiratory Control and Bispectral Index

• Published in: Anesthesiology (Philadelphia) Vol. 98; no. 2; pp. 312 - 322
• Main Authors: Nieuwenhuijs, Diederik J.F., Olofsen, Erik, Romberg, Raymonda R., Sarton, Elise, Ward, Denham, Engbers, Frank, Vuyk, Jaap, Mooren, Rene, Teppema, Luc J, Dahan, Albert
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01.02.2003
• Subjects: Adult; Analgesics; Analgesics, Opioid - pharmacology; Anesthetics, Intravenous - pharmacology; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Blood Pressure - drug effects; Carbon Dioxide - blood; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography - drug effects; Heart Rate - drug effects; Hemodynamics - drug effects; Humans; Hypercapnia - blood; Hypercapnia - physiopathology; Male; Medical sciences; Models, Biological; Neuropharmacology; Pharmacology. Drug treatments; Piperidines - pharmacology; Propofol - pharmacology; Remifentanil; Respiratory Mechanics - drug effects; Human; Pharmacokinetic pharmacodynamic relationship; Drug combination; Healthy subject; Male; Opiates; Electroencephalography; Narcotic analgesic; Spectral analysis; Remifentanil; Dose activity relation; General anesthetic; Activity concentration relation; Drug interaction; Models; Hemodynamics; Propofol; Respiratory control; Induced hypercapnia; Respiration

Since propofol and remifentanil are frequently combined for monitored anesthesia care, we examined the influence of the separate and combined administration of these agents on cardiorespiratory control and bispectral index in humans. The effect of steady-state concentrations of remifentanil and prop...