Novel effects with polyethylene glycol modified pharmaceuticals

• Published in: Cancer treatment reviews Vol. 28; pp. 3 - 6
• Main Authors: Yowell, S.L., Blackwell, S.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.2002; Elsevier
• Subjects: Animals; Antineoplastic agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacokinetics; Biological and medical sciences; Chemotherapy; Doxorubicin - administration & dosage; Doxorubicin - analogs & derivatives; Doxorubicin - pharmacokinetics; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug Stability; Filgrastim; Granulocyte Colony-Stimulating Factor - administration & dosage; Granulocyte Colony-Stimulating Factor - analogs & derivatives; Granulocyte Colony-Stimulating Factor - pharmacokinetics; Half-Life; Humans; Intestinal Absorption; Liposomes; Medical sciences; Metabolic Clearance Rate; Neoplasms - blood supply; Neoplasms - drug therapy; Neoplasms, Experimental - blood supply; Neoplasms, Experimental - drug therapy; oncology; Patient Acceptance of Health Care; pegfilgrastim; pegylated liposomal doxorubicin; Pegylation; Pharmacology. Drug treatments; Polyethylene Glycols - administration & dosage; Polyethylene Glycols - chemistry; Polyethylene Glycols - pharmacokinetics; Recombinant Proteins; pegfilgrastim; pegylated liposomal doxorubicin; Pegylation; oncology; Antineoplastic agent; Human; Liposome; Drug carrier; Review; Doxorubicin; Filgrastim; Ethylene oxide polymer; Chemotherapy; Treatment; Dosage form; Coated particle; Anthracyclins; Conjugated compound; Pharmacokinetics

Proteins undergo extensive hydrolysis in the gastrointestinal tract and have short circulating half-lives in the blood, For optimal clinical efficacy, therefore, they must be given by daily injections. Attaching a polyethylene glycol (PEG) moiety (pegylation) improves the pharmacokinetic and pharmac...