Magnetic guanidyl–functionalized covalent organic framework composite: a platform for specific capture and isolation of phosphopeptides and exosomes

• Published in: Mikrochimica acta (1966) Vol. 189; no. 9; p. 330
• Main Authors: Wang, Bing, Wang, Baichun, Feng, Quanshou, Fang, Xiang, Dai, Xinhua, Yan, Yinghua, Ding, Chuan-Fan
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.09.2022; Springer; Springer Nature B.V
• Subjects: Albumins; Analytical Chemistry; Binding sites; Casein; Cattle; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Enrichment; Gold; Iron oxides; Microengineering; Nanochemistry; Nanocomposites; Nanoparticles; Nanotechnology; Original Paper; Polyethyleneimine; Proteins; Selectivity; Serum proteins; Enrichment; Size exclusion; SDS-Page; Covalent organic framework; Phosphopeptides; Exosomes; Mass spectrometry

A guanidine-functionalized (GF) covalent organic framework (COF) nanocomposite has been developed by a post-synthetic approach for specific capture and separation of phosphopeptides and exosomes. The abundant binding sites on COF can immobilize a large number of gold nanoparticles (AuNPs), which can...