Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth-muscle cell proliferation in a rat carotid balloon-injury model

• Published in: The American heart journal Vol. 133; no. 3; pp. 329 - 334
• Main Authors: Gottsauner-Wolf, Michael, Jang, Yangsoo, Lincoff, A.Michael, Cohen, Joel L., Labhasetwar, Vinod, Poptic, Earl J., Forudi, Farhad, Guzman, Luis A., DiCorleto, Paul E., Levy, Robert J., Topol, Eric J., Ellis, Stephen G.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.03.1997; Elsevier
• Subjects: Animals; Biological and medical sciences; Cardiovascular system; Carotid Artery, Common - pathology; Cell Division - drug effects; Cells, Cultured; Disease Models, Animal; Drug Delivery Systems; Male; Medical sciences; Muscle, Smooth - cytology; Nitriles - administration & dosage; Pharmacology. Drug treatments; Phenols - administration & dosage; Polymers; Protein-Tyrosine Kinases - antagonists & inhibitors; Rats; Rats, Sprague-Dawley; Tunica Intima - pathology; Tunica Intima - physiology; Tyrphostins; Vascular wall; Cell proliferation; Tyrosine; Rat; Enzyme; Transferases; Treatment efficiency; Rodentia; Instrumentation therapy; Enzyme inhibitor; Smooth muscle; Instrumental dilatation; In vitro; In vivo; Local administration; Vertebrata; Chemotherapy; Mammalia; Treatment; Kinase; Animal; Carotid

Smooth-muscle cell proliferation in response to arterial injury represents an important etiologic factor in restenosis after angioplasty. Tyrphostin-47, a protein tyrosine kinase inhibitor, inhibits smooth-muscle cell proliferation in vitro. In this study tyrphostin-47 was incorporated into matrixes...