Protective effect of bradykinin antagonist Hoe-140 during in vivo myocardial ischemic-reperfusion injury in the cat

• Published in: Regulatory peptides Vol. 115; no. 3; pp. 211 - 218
• Main Authors: Kumari, Rashmi, Maulik, Mohua, Manchanda, Subhash Chandra, Maulik, Subir Kumar
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 15.10.2003; Amsterdam Elsevier
• Subjects: Adenosine Triphosphate - metabolism; Animals; Biological and medical sciences; Bradykinin - analogs & derivatives; Bradykinin - pharmacology; Bradykinin antagonist; Bradykinin Receptor Antagonists; Cat; Cats; Fundamental and applied biological sciences. Psychology; Ischemic-reperfusion injury; Myocardial Ischemia - metabolism; Myocardial Reperfusion Injury - drug therapy; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - mortality; Myocardium - enzymology; Myocardium - metabolism; Oxidative Stress - drug effects; Protective Agents - pharmacology; Thiobarbituric Acid Reactive Substances - metabolism; Time Factors; Vertebrates: endocrinology; Ischemic-reperfusion injury; Bradykinin antagonist; Cat; Fissipedia; Carnivora; Peptide hormone; Neuropeptide; Felis catus; In vivo; Vertebrata; Mammalia; Reperfusion; Bradykinin; Antagonist

The effect of icatibant (Hoe-140), a selective bradykinin receptor (B 2) antagonist on myocardial ischemic-reperfusion injury was studied in open chest barbiturate anaesthetized cats. The left anterior descending coronary artery was occluded for 15 min, followed by 60 min of reperfusion. Saline or i...