Synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration
Experiments were conducted to examine the possible interaction between retinal taurine depletion and environmental lighting in causing photoreceptor cell degeneration. Albino rats were raised from birth in either dim (2 lx) or relatively bright (300 lx) cyclic light. Beginning at weaning, half the a...
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Published in | Experimental eye research Vol. 46; no. 2; pp. 229 - 238 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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England
Elsevier Ltd
01.02.1988
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Abstract | Experiments were conducted to examine the possible interaction between retinal taurine depletion and environmental lighting in causing photoreceptor cell degeneration. Albino rats were raised from birth in either dim (2 lx) or relatively bright (300 lx) cyclic light. Beginning at weaning, half the animals from both light environments were taurine-depleted by treating them for 10 weeks with guanidinoetyl sulfonate as a 1% solution in their drinking water. The remaining animals were given ordinary tap-water and served as controls. In the 2 lx light environment, taurine depletion caused a decrease in electroretinogram (ERG) a- and b-wave amplitude of 36 and 46%, respectively; however, no photoreceptor cells were lost in this group. Tap-water controls kept in the 300 lx light environment had a 59- and 43% decrease in ERG a- and b-wave amplitude, respectively, and a 21% reduction in the number of photoreceptor cells. In contrast to the other groups, animals that were taurine-depleted in the 300 lx environment showed a marked retinal degeneration. ERG a- and b-wave amplitude was decreased by 94- and 89% respectively and there was a 62% loss of photoreceptor cells. The greatest cell loss occurred in the central superior region of the retina, in which the outer nuclear layer was typically reduced to one to two rows of nuclei. The results of a two-way analysis of variance applied to the data indicated that the effects of taurine depletion on the retina were greater in the 300, lx as compared with the 2 lx environment in terms of loss of photoreceptor cells and reduction in log ERG a- and b-wave amplitude. These findings demonstrate a synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration. |
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AbstractList | Experiments were conducted to examine the possible interaction between retinal taurine depletion and environmental lighting in causing photoreceptor cell degeneration. The results indicated that the effects of taurine depletion on the retina were greater in the relatively bright (300 1x) cyclic light as compared with the dim (2 1x) environment in terms of loss of photoreceptor cells and reduction in log electroretinogram (ERG) a- and b-wave amplitude. The findings demonstrate a synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration. Experiments were conducted to examine the possible interaction between retinal taurine depletion and environmental lighting in causing photoreceptor cell degeneration. Albino rats were raised from birth in either dim (2 lx) or relatively bright (300 lx) cyclic light. Beginning at weaning, half the animals from both light environments were taurine-depleted by treating them for 10 weeks with guanidinoethyl sulfonate as a 1% solution in their drinking water. The remaining animals were given ordinary tap-water and served as controls. In the 2 lx light environment, taurine depletion caused a decrease in electroretinogram (ERG) a- and b-wave amplitude of 36 and 46%, respectively; however, no photoreceptor cells were lost in this group. Tap-water controls kept in the 300 lx light environment had a 59- and 43% decrease in ERG a- and b-wave amplitude, respectively, and a 21% reduction in the number of photoreceptor cells. In contrast to the other groups, animals that were taurine-depleted in the 300 lx environment showed a marked retinal degeneration. ERG a- and b-wave amplitude was decreased by 94- and 89% respectively and there was a 62% loss of photoreceptor cells. The greatest cell loss occurred in the central superior region of the retina, in which the outer nuclear layer was typically reduced to one to two rows of nuclei. The results of a two-way analysis of variance applied to the data indicated that the effects of taurine depletion on the retina were greater in the 300 lx as compared with the 2 lx environment in terms of loss of photoreceptor cells and reduction in log ERG a- and b-wave amplitude. These findings demonstrate a synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration. Experiments were conducted to examine the possible interaction between retinal taurine depletion and environmental lighting in causing photoreceptor cell degeneration. Albino rats were raised from birth in either dim (2 lx) or relatively bright (300 lx) cyclic light. Beginning at weaning, half the animals from both light environments were taurine-depleted by treating them for 10 weeks with guanidinoetyl sulfonate as a 1% solution in their drinking water. The remaining animals were given ordinary tap-water and served as controls. In the 2 lx light environment, taurine depletion caused a decrease in electroretinogram (ERG) a- and b-wave amplitude of 36 and 46%, respectively; however, no photoreceptor cells were lost in this group. Tap-water controls kept in the 300 lx light environment had a 59- and 43% decrease in ERG a- and b-wave amplitude, respectively, and a 21% reduction in the number of photoreceptor cells. In contrast to the other groups, animals that were taurine-depleted in the 300 lx environment showed a marked retinal degeneration. ERG a- and b-wave amplitude was decreased by 94- and 89% respectively and there was a 62% loss of photoreceptor cells. The greatest cell loss occurred in the central superior region of the retina, in which the outer nuclear layer was typically reduced to one to two rows of nuclei. The results of a two-way analysis of variance applied to the data indicated that the effects of taurine depletion on the retina were greater in the 300, lx as compared with the 2 lx environment in terms of loss of photoreceptor cells and reduction in log ERG a- and b-wave amplitude. These findings demonstrate a synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration. |
Author | Rapp, Laurence M. Anderson, Robert E. Thum, Lisa A. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3350067$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/0014-4835(86)90070-9 10.1007/BF00964706 10.1111/j.1471-4159.1976.tb01519.x 10.1016/S0014-4835(86)80045-8 10.1111/j.1471-4159.1980.tb09010.x 10.1002/jnr.490060309 10.1126/science.1138364 10.1016/S0014-4835(87)80041-6 10.1016/0006-8993(85)90018-6 10.1016/S0014-4835(87)80169-0 10.1007/BF00965643 10.1136/bjo.66.12.771 10.1095/biolreprod29.3.548 10.1016/0039-6257(78)90070-X 10.1016/0014-4835(78)90134-3 10.1016/0014-4835(86)90020-5 10.1016/0006-2944(83)90007-8 10.1016/0006-8993(76)90099-8 10.1083/jcb.14.1.73 10.1002/jnr.490090205 |
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Keywords | taurine depletion synergism albino rats guanidinoethyl sulfonate electro-retinogram cyclic light light environment photoreceptor cell |
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SubjectTerms | albino rats Animals Animals, Newborn cyclic light electro-retinogram Electroretinography Female guanidinoethyl sulfonate light environment Lighting - adverse effects Photometry photoreceptor cell Photoreceptor Cells - pathology Rats Rats, Inbred Strains Retina - physiopathology Retinal Degeneration - etiology Retinal Degeneration - pathology synergism Taurine - administration & dosage taurine depletion |
Title | Synergism between environmental lighting and taurine depletion in causing photoreceptor cell degeneration |
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