Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats

• Published in: European journal of pharmacology Vol. 644; no. 1-3; pp. 146 - 153
• Main Authors: Jaiswal, Amardeep, Kumar, Santosh, Enjamoori, Rajesh, Seth, Sandeep, Dinda, Amit Kumar, Maulik, Subir Kumar
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10.10.2010; Elsevier
• Subjects: Animals; Antioxidants - metabolism; Benzodiazepinones - administration & dosage; Benzodiazepinones - pharmacology; Biological and medical sciences; Cardiomegaly - physiopathology; Cardiomegaly - prevention & control; Disease Models, Animal; Dose-Response Relationship, Drug; Echocardiography; Fibrosis; Fibrosis - physiopathology; Fibrosis - prevention & control; Isoproterenol; Lipid Peroxidation - drug effects; Male; Medical sciences; Myocyte size; Myosin heavy chain; Myosin Heavy Chains - drug effects; Myosin Heavy Chains - genetics; Oxidative stress; Oxidative Stress - drug effects; Pharmacology. Drug treatments; Rats; Rats, Wistar; Receptors, GABA-A - metabolism; Oxidative stress; Myosin heavy chain; Echocardiography; Myocyte size; Fibrosis; Heart; Peripheral benzodiazepine receptor; Agonist; Heavy peptide chain; Isoprenaline; Rat; Ligand; Bronchodilator; Rodentia; β2-Adrenergic receptor; β-Adrenergic receptor agonist; β-Adrenergic receptor; Myocyte; Vertebrata; Mammalia; Animal; Myosin; Circulatory system; Hypertrophy

Oxidative stress plays a significant role in the pathogenesis of cardiac hypertrophy. Peripheral benzodiazepine receptors are ubiquitously expressed in various tissues, including the heart. Peripheral benzodiazepine receptors have been reported to be involved in the protection of cells against oxyge...