Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFκB inflammatory axis in coronary artery disease

• Published in: Atherosclerosis Vol. 389; p. 117436
• Main Authors: Basu, Pratitusti, Das, Apabrita Ayan, Siddiqui, Khawer N., Mondal, Prakas C., Bandyopadhyay, Arun
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.02.2024
• Subjects: Animals; Apolipoproteins E - metabolism; Atherosclerosis; Atherosclerosis - pathology; Carrier Proteins - metabolism; Case-Control Studies; Coronary Artery Disease; Cytokines; Cytokines - metabolism; Humans; Inflammation; Inflammation - metabolism; Macrophages; Mice; N-Acetylmuramoyl-L-alanine Amidase - metabolism; Nod2 Signaling Adaptor Protein - genetics; Nod2 Signaling Adaptor Protein - metabolism; Inflammation; Cytokines; Macrophages; Coronary artery disease; Atherosclerosis

The role of inflammation in driving atherosclerosis is well-established. It exerts systemic effects beyond the local site of plaque formation. In the context of coronary artery disease (CAD), the proteins that show altered levels in the plasma, are potentially important for understanding the key reg...