Analysis of HNE metabolism in CNS models

The formation and toxicity of trans-4-hydroxy-2-nonenal in the central nervous system is well documented. However, the metabolism of HNE in the central nervous system (CNS) is not clear. HNE metabolism in the CNS appears to be different from that in other tissues and organs and may be dependent on t...

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Published inRedox report : communications in free radical research Vol. 12; no. 1-2; pp. 16 - 19
Main Authors Kubatova, Alena, Honzatko, Ales, Brichac, Jiri, Long, Eric, Picklo, Matthew J.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.02.2007
Subjects
Aldehydes - metabolism
Alzheimer Disease - metabolism
Animals
CENTRAL NERVOUS SYSTEM
Central Nervous System - physiology
Humans
Mitochondria, Heart - metabolism
Models, Neurological
Oxidation-Reduction
Parkinson Disease - metabolism
STEREOCENTER
TRANS-4-HYDROXY-2-NONENAL
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Abstract The formation and toxicity of trans-4-hydroxy-2-nonenal in the central nervous system is well documented. However, the metabolism of HNE in the central nervous system (CNS) is not clear. HNE metabolism in the CNS appears to be different from that in other tissues and organs and may be dependent on the cell type and subcellular environment. Our data show that HNE metabolism is affected by the stereocenter of HNE and that oxidation of HNE may be a primary route of metabolism. Further metabolic analysis of HNE disposition is needed to clarify which pathways are truly important in normal and pathological states in the CNS.
AbstractList The formation and toxicity of trans-4-hydroxy-2-nonenal in the central nervous system is well documented. However, the metabolism of HNE in the central nervous system (CNS) is not clear. HNE metabolism in the CNS appears to be different from that in other tissues and organs and may be dependent on the cell type and subcellular environment. Our data show that HNE metabolism is affected by the stereocenter of HNE and that oxidation of HNE may be a primary route of metabolism. Further metabolic analysis of HNE disposition is needed to clarify which pathways are truly important in normal and pathological states in the CNS.
Author Brichac, Jiri
Picklo, Matthew J.
Long, Eric
Kubatova, Alena
Honzatko, Ales
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Snippet The formation and toxicity of trans-4-hydroxy-2-nonenal in the central nervous system is well documented. However, the metabolism of HNE in the central nervous...
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SubjectTerms Aldehydes - metabolism
Alzheimer Disease - metabolism
Animals
CENTRAL NERVOUS SYSTEM
Central Nervous System - physiology
Humans
Mitochondria, Heart - metabolism
Models, Neurological
Oxidation-Reduction
Parkinson Disease - metabolism
STEREOCENTER
TRANS-4-HYDROXY-2-NONENAL
Title Analysis of HNE metabolism in CNS models
URI https://www.tandfonline.com/doi/abs/10.1179/135100007X162149
https://www.ncbi.nlm.nih.gov/pubmed/17263902
Volume 12
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