Immunobiology of hepatitis B virus infection

• Published in: Hepatology research Vol. 45; no. 2; pp. 179 - 189
• Main Authors: Isogawa, Masanori, Tanaka, Yasuhito
• Format: Journal Article
• Language: English
• Published: Netherlands Blackwell Publishing Ltd 01.02.2015
• Subjects: hepatitis B virus; immune response; immunological priming; immunotherapy; T cells; T cells; immune response; hepatitis B virus; immunological priming; immunotherapy

The adaptive immune response, particularly the virus‐specific CD8+ T‐cell response, is largely responsible for viral clearance and disease pathogenesis during hepatitis B virus (HBV) infection. The HBV‐specific CD8+ T‐cell response is vigorous, polyclonal and multispecific in acutely infected patien...