Differential role of angiogenesis and tumour cell proliferation in brain metastases according to primary tumour type: analysis of 639 cases

• Published in: Neuropathology and applied neurobiology Vol. 41; no. 2; pp. e41 - e55
• Main Authors: Berghoff, Anna S., Ilhan-Mutlu, Aysegül, Dinhof, Carina, Magerle, Manuel, Hackl, Monika, Widhalm, Georg, Hainfellner, Johannes A., Dieckmann, Karin, Pichler, Josef, Hutterer, Markus, Melchardt, Thomas, Bartsch, Rupert, Zielinski, Christoph C., Birner, Peter, Preusser, Matthias
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2015; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Angiogenesis; brain metastases; Brain Neoplasms - blood supply; Brain Neoplasms - mortality; Brain Neoplasms - secondary; Breast cancer; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Carcinoma, Renal Cell - mortality; Carcinoma, Renal Cell - pathology; Cell Proliferation; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Female; HIF-1 alpha index; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - analysis; Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen - analysis; ki67 proliferation index; Lung cancer; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Melanoma; Melanoma - mortality; Melanoma - pathology; microvascular density; Middle Aged; Neovascularization, Pathologic - mortality; Neovascularization, Pathologic - pathology; Proportional Hazards Models; ki67 proliferation index; microvascular density; HIF-1 alpha index; brain metastases

Aim We aimed to characterize angiogenesis and proliferation and their correlation with clinical characteristics in a large brain metastasis (BM) series. Methods Ki67 proliferation index, microvascular density (MVD) and hypoxia‐inducible factor 1 alpha (HIF‐1 alpha) index were determined by immunohis...