Quercetin Induces Antiproliferative Activity Against Human Hepatocellular Carcinoma (HepG2) Cells by Suppressing Specificity Protein 1 (Sp1)

• Published in: Drug development research Vol. 76; no. 1; pp. 9 - 16
• Main Authors: Lee, Ra Ham, Cho, Jin Hyoung, Jeon, Young-Joo, Bang, Woong, Cho, Jung-Jae, Choi, Nag-Jin, Seo, Kang Seok, Shim, Jung-Hyun, Chae, Jung-Il
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.02.2015; Wiley Subscription Services, Inc
• Subjects: antiproliferative; Apoptosis; Cell cycle; Cell growth; human hepatocellular carcinoma; Liver cancer; Proteins; quercetin; specificity protein 1; apoptosis; quercetin; antiproliferative; specificity protein 1; human hepatocellular carcinoma

ABSTRACT Preclinical Research Quercetin, found in red onions and red apple skin can induce apoptosis insome malignant cells. However, the apoptotic effect of quercetin in hepatocellular carcinoma HepG2 cells via regulation of specificity protein 1 (Sp1) has not been studied. Here, we demonstrated th...