Epithelial lesions in prophylactic mastectomy specimens from women with BRCA mutations

• Published in: Cancer Vol. 97; no. 7; pp. 1601 - 1608
• Main Authors: Kauff, Noah D., Brogi, Edi, Scheuer, Lauren, Pathak, Dorothy R., Borgen, Patrick I., Hudis, Clifford A., Offit, Kenneth, Robson, Mark E.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.04.2003; Wiley-Liss
• Subjects: Adult; Biological and medical sciences; Biopsy; BRCA1; BRCA2; Breast - anatomy & histology; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Carcinoma in Situ - genetics; Carcinoma in Situ - pathology; Female; Genes, BRCA1; Gynecology. Andrology. Obstetrics; hereditary breast carcinoma; Humans; Mammary gland diseases; Mastectomy; Medical sciences; Middle Aged; Mutation; pathology; prophylactic mastectomy; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the genital tract and mammary gland; Tumors; Human; Carcinoma; Malignant tumor; Hereditary; prophylactic mastectomy; Genetic disease; Prevention; Mammary gland diseases; BRCA1, BRCA2, hereditary breast carcinoma, pathology; Surgery; Mastectomy; Genetics; Mammary gland; Mutation; Tumor suppressor gene

BACKGROUND It has been suggested that BRCA‐associated breast carcinoma may often lack a detectable preinvasive phase. To investigate this hypothesis, the authors compared the prevalence of histopathologic lesions in prophylactic mastectomy (PM) specimens from women with BRCA mutations and in mastect...