Programmed cell death‐1 3′‐untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection

• Published in: Journal of medical virology Vol. 90; no. 11; pp. 1730 - 1738
• Main Authors: Chihab, Hajar, Jadid, Fatima‐Zahra, Foka, Pelagia, Zaidane, Imane, El Fihry, Raouia, Georgopoulou, Urania, Marchio, Agnes, Elhabazi, Abdellah, Chair, Mohammed, Pineau, Pascal, Ezzikouri, Sayeh, Benjelloun, Soumaya
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2018; Wiley-Blackwell
• Subjects: 3' Untranslated Regions; Adult; Aged; Apoptosis; CD8 antigen; Cell activation; Cell death; chronic hepatitis B virus infection; Chronic infection; Confidence intervals; Female; Gene expression; Gene Expression Profiling; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Genotypes; Hepatitis; Hepatitis B; Hepatitis B virus; Humans; Immune clearance; Immunological tolerance; Immunosuppression; Infections; Life Sciences; Lymphocytes; Lymphocytes T; Male; Microbiology and Parasitology; Middle Aged; Morocco; Patients; PD-1 protein; PD‐1 polymorphism; Peripheral blood; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Programmed Cell Death 1 Receptor; programmed cell death‐1; Ribonucleic acid; RNA; spontaneous clearance; Virology; Viruses; spontaneous clearance; PD-1 polymorphism; chronic hepatitis B virus infection; programmed cell death-1

Hepatitis B virus (HBV)‐specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death‐1 (PD‐1), an immunosuppressive molecule that regulates T‐cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs1...