Programmed cell death‐1 3′‐untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection

Hepatitis B virus (HBV)‐specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death‐1 (PD‐1), an immunosuppressive molecule that regulates T‐cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs1...

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Published inJournal of medical virology Vol. 90; no. 11; pp. 1730 - 1738
Main Authors Chihab, Hajar, Jadid, Fatima‐Zahra, Foka, Pelagia, Zaidane, Imane, El Fihry, Raouia, Georgopoulou, Urania, Marchio, Agnes, Elhabazi, Abdellah, Chair, Mohammed, Pineau, Pascal, Ezzikouri, Sayeh, Benjelloun, Soumaya
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.11.2018
Wiley-Blackwell
Subjects
3' Untranslated Regions
Adult
Aged
Apoptosis
CD8 antigen
Cell activation
Cell death
chronic hepatitis B virus infection
Chronic infection
Confidence intervals
Female
Gene expression
Gene Expression Profiling
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotypes
Hepatitis
Hepatitis B
Hepatitis B virus
Humans
Immune clearance
Immunological tolerance
Immunosuppression
Infections
Life Sciences
Lymphocytes
Lymphocytes T
Male
Microbiology and Parasitology
Middle Aged
Morocco
Patients
PD-1 protein
PD‐1 polymorphism
Peripheral blood
Polymerase chain reaction
Polymorphism
Polymorphism, Single Nucleotide
Programmed Cell Death 1 Receptor
programmed cell death‐1
Ribonucleic acid
RNA
spontaneous clearance
Virology
Viruses
spontaneous clearance
PD-1 polymorphism
chronic hepatitis B virus infection
programmed cell death-1
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Abstract Hepatitis B virus (HBV)‐specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death‐1 (PD‐1), an immunosuppressive molecule that regulates T‐cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single‐nucleotide polymorphism in the 3′‐untranslated region (3′‐UTR) of PD‐1, has been associated with susceptibility and disease progression of chronic HBV infection in far‐eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD‐1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse‐transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P = 0.038) against HBV infection. Interestingly, PD‐1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD‐1 mRNA compared with corresponding genotypes in resolved subjects (P = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV‐infected patients carrying PD‐1 GG and GA genotypes at rs10204525 have high PD‐1 mRNA expression and may be more prone to installation of chronicity.
AbstractList Hepatitis B virus (HBV)‐specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death‐1 (PD‐1), an immunosuppressive molecule that regulates T‐cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525 , a single‐nucleotide polymorphism in the 3′‐untranslated region (3′‐UTR) of PD‐1 , has been associated with susceptibility and disease progression of chronic HBV infection in far‐eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD‐1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse‐transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P  = 0.038) against HBV infection. Interestingly, PD‐1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD‐1 mRNA compared with corresponding genotypes in resolved subjects ( P  = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV‐infected patients carrying PD‐1 GG and GA genotypes at rs10204525 have high PD‐1 mRNA expression and may be more prone to installation of chronicity.
Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T-cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single-nucleotide polymorphism in the 3'-untranslated region (3'-UTR) of PD-1, has been associated with susceptibility and disease progression of chronic HBV infection in far-eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD-1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse-transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P = 0.038) against HBV infection. Interestingly, PD-1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD-1 mRNA compared with corresponding genotypes in resolved subjects (P = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV-infected patients carrying PD-1 GG and GA genotypes at rs10204525 have high PD-1 mRNA expression and may be more prone to installation of chronicity.Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T-cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single-nucleotide polymorphism in the 3'-untranslated region (3'-UTR) of PD-1, has been associated with susceptibility and disease progression of chronic HBV infection in far-eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD-1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse-transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P = 0.038) against HBV infection. Interestingly, PD-1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD-1 mRNA compared with corresponding genotypes in resolved subjects (P = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV-infected patients carrying PD-1 GG and GA genotypes at rs10204525 have high PD-1 mRNA expression and may be more prone to installation of chronicity.
Hepatitis B virus (HBV)‐specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death‐1 (PD‐1), an immunosuppressive molecule that regulates T‐cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single‐nucleotide polymorphism in the 3′‐untranslated region (3′‐UTR) of PD‐1, has been associated with susceptibility and disease progression of chronic HBV infection in far‐eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD‐1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse‐transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P = 0.038) against HBV infection. Interestingly, PD‐1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD‐1 mRNA compared with corresponding genotypes in resolved subjects (P = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV‐infected patients carrying PD‐1 GG and GA genotypes at rs10204525 have high PD‐1 mRNA expression and may be more prone to installation of chronicity.
Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive molecule that regulates T-cell activation and peripheral immune tolerance, is increasingly shown to influence the outcome of HBV infection. rs10204525, a single-nucleotide polymorphism in the 3'-untranslated region (3'-UTR) of PD-1, has been associated with susceptibility and disease progression of chronic HBV infection in far-eastern patients. The aim of our study was to assess the impact of rs10204525 variation on HBV infection in Moroccan patients. A total of 236 patients with chronic HBV infection and 134 individuals with spontaneous HBV resolution were genotyped using a Taqman assay. In addition, PD-1 mRNA expression in peripheral blood nuclear cells was determined by quantitative reverse-transcription polymerase chain reaction. We found that the AA genotype is protective (odds ratio, 0.43; 95% confidence interval, 0.19 to 0.97; P = 0.038) against HBV infection. Interestingly, PD-1 messenger RNA (mRNA) expression analysis has revealed that chronic HBV carriers with GG and GA displayed higher levels of PD-1 mRNA compared with corresponding genotypes in resolved subjects (P = 0.031 and 0.014, respectively). Our data suggest that Mediterranean HBV-infected patients carrying PD-1 GG and GA genotypes at rs10204525 have high PD-1 mRNA expression and may be more prone to installation of chronicity.
Author El Fihry, Raouia
Benjelloun, Soumaya
Chihab, Hajar
Zaidane, Imane
Pineau, Pascal
Georgopoulou, Urania
Marchio, Agnes
Foka, Pelagia
Ezzikouri, Sayeh
Elhabazi, Abdellah
Chair, Mohammed
Jadid, Fatima‐Zahra
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Issue 11
Keywords spontaneous clearance
PD-1 polymorphism
chronic hepatitis B virus infection
programmed cell death-1
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Snippet Hepatitis B virus (HBV)‐specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death‐1 (PD‐1), an immunosuppressive...
Hepatitis B virus (HBV)-specific CD8+ T cells play an important role in the clearance of HBV infection. Programmed cell death-1 (PD-1), an immunosuppressive...
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SubjectTerms 3' Untranslated Regions
Adult
Aged
Apoptosis
CD8 antigen
Cell activation
Cell death
chronic hepatitis B virus infection
Chronic infection
Confidence intervals
Female
Gene expression
Gene Expression Profiling
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotypes
Hepatitis
Hepatitis B
Hepatitis B virus
Humans
Immune clearance
Immunological tolerance
Immunosuppression
Infections
Life Sciences
Lymphocytes
Lymphocytes T
Male
Microbiology and Parasitology
Middle Aged
Morocco
Patients
PD-1 protein
PD‐1 polymorphism
Peripheral blood
Polymerase chain reaction
Polymorphism
Polymorphism, Single Nucleotide
Programmed Cell Death 1 Receptor
programmed cell death‐1
Ribonucleic acid
RNA
spontaneous clearance
Virology
Viruses
Title Programmed cell death‐1 3′‐untranslated region polymorphism is associated with spontaneous clearance of hepatitis B virus infection
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmv.25265
https://www.ncbi.nlm.nih.gov/pubmed/30016557
https://www.proquest.com/docview/2112206006
https://www.proquest.com/docview/2071574089
https://pasteur.hal.science/pasteur-02611937
Volume 90
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